Protein Misfolding and Human Diseases Deciphering the Central Role of Pathological Aggregation
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Form:Einzelkauf Download
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Sprache:Englisch
157,99 €
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
ePUB 3
Kopierschutz
Nein
Family Sharing
Nein
Text-to-Speech
Ja
Erscheinungsdatum
06.07.2026
Herausgeber
Pranav Kumar Prabhakar + weitereVerlag
Elsevier Science & Techn.Seitenzahl
400 (Printausgabe)
Dateigröße
13393 KB
Sprache
Englisch
EAN
9780443366376
Protein Misfolding and Human Diseases: Deciphering the Central Role of Pathological Aggregation investigates the misfolding of proteins and implications for a variety of debilitating conditions. The book comprehensively overviews pathological protein aggregation, exploring its mechanisms in specific illnesses, including Alzheimer's disease, Parkinson's disease, Huntington's disease, prion diseases, ALS, and systemic amyloidosis. It addresses disrupted cellular pathways and failures in protein homeostasis during aging, delineating the unifying principles across protein conformational disorders. Sections feature structural insights into protein aggregates from amyloid fibrils to inclusion bodies and offer therapeutic strategies to disrupt aggregation pathways, enhance cellular protein quality control, and provide immunotherapy solutions.Finally, the book closes with a discussion of the latest advances in research and considerations for future directions to combat protein aggregation. It will serve as an invaluable reference on the intricacies of protein misfolding and its clinical implications. Researchers, academics and graduate students working across these fields will benefit from this comprehensive guide. Additionally, clinicians and healthcare professionals will find it invaluable for understanding the molecular basis of protein misfolding disorders.
- Offers insights into the molecular mechanisms underlying protein misfolding and aggregation and their pathological consequences
- Explores potential therapeutic strategies for protein folding diseases
- Combines interdisciplinary perspectives from experts across a diverse range of fields, including structural biology, biophysics, cell biology, biochemistry, neuroscience, and clinical research
- Features case studies, key terms, and learning objectives to enhance understanding
- Offers insights into the molecular mechanisms underlying protein misfolding and aggregation and their pathological consequences
- Explores potential therapeutic strategies for protein folding diseases
- Combines interdisciplinary perspectives from experts across a diverse range of fields, including structural biology, biophysics, cell biology, biochemistry, neuroscience, and clinical research
- Features case studies, key terms, and learning objectives to enhance understanding
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