Chapter 1 Types and Classifications of Headaches ¿rem YILDIRIM, Aynur ÖZGE Chapter 2 Current Explanation for Trigeminovascular System and Central Sensitization Müge YEM¿¿Ç¿ , Talha Berk BOLU, Hülya KARATA¿ KUR¿UN Chapter 3 Impact of Headaches on Sleep Architecture Tuba CERRAHO¿LU ¿¿R¿N Chapter 4 Neurobiological Mechanisms of Sleep Regulation Mona HUSSAIN Chapter 5 Overview of Insomnia, Sleep Apnea, and Circadian Rhythm Disorders Rehab MAGDY, Güldeniz ÇET¿N ERC¿ Chapter 6 Impact of Comorbidities on Headaches and Sleep Disorders Berin GÜLATAR TÜRKO¿LU , Buse Çäla ARI Chapter 7 Mutual Influence of Sleep Disorders and Headache in Childhood Zeynep Ece TOKSOY, ¿brahim ADAK Chapter 8 Current Genetic Associations with Clock Genes and Covariates Information Classification: General Giacomo RACIOPPI, Alessandra VOCI, Romina MOAVERO, Laura PAPETTI, Massimiliano VALERIANI Chapter 9 Potential Role of Frontostriatal Circuit Demet AYGÜN ÜSTEL, Hamit GENÇ Chapter 10 Potential Role of Epigenetic Mechanisms on the Headache-Sleep Disorders Association Turan POYRAZ, Gökhan GÜREL, Vincenzo GUIDETTI Chapter 11 Hallmarks of Neurodegenerative Disorders Hindol CHAKRABORTY Chapter 12 Common Sleep and Pain-Related Symptoms in Neurodegeneration Berkant An¿l ÖZÇEL¿K, Hatice ÇET¿N Chapter 13 Mechanisms Linking Neurodegeneration to Sleep and Headache Pathologies Ye¿im KAYA, A¿¿t ÇET¿NKAYA. Kübra HACIBEYO¿LU Chapter 14 How Sleep Modulates Headache Frequency and Severity Parisa GAZERANI Chapter 15 Headache Disorders as Precursors to Sleep Dysregulation Ay¿enur ¿AH¿N, P¿nar YALINAY D¿KMEN Chapter 16 Shared Pathways in Headache and Sleep Disorders Vildan ALTUNAYO¿LU ÇAKMAK, Sibel K.VEL¿O¿LU Chapter 17 REM Sleep Behavior Disorder and Restless Legs Syndrome in Alpha-Synucleinopathies Pelin YEN¿LMEZ YE¿¿LDA¿, ¿nci MÜLKEM ¿¿M¿EK Chapter 18 Information Classification: General Sleep Disorders in Dementia Arzu ALDEM¿R, Derya BAYRAK Chapter 19 Circadian Disruption in Huntington Disease and Prion Diseases Gülcan GÖÇMEZ YILMAZ , Tuba AKINCI Chapter 20 Crossing Pathways Between Sleep Disorders and Neurodegenerative Disorders Fatma Gülhan ¿AHBAZ, Esra DEM¿R ÜNAL Chapter 21 Bidirectional Links Between Insomnia and Neurodegeneration Nur TÜRKMEN, Gizem GÜRSOY Chapter 22 Role of Neuroinflammation and Glial Activation Can ULUTA¿, Rah¿an KARACI Chapter 23 Dopaminergic, Serotonergic, and Orexinergic Pathways Esra KOCHAN KIZILKILIC, Esma KOBAK TUR Chapter 24 Mitochondrial Dysfunction and Oxidative Stress Nermin TEPE, Tuba ERDO¿AN SOYUKIBAR Chapter 25 Impact of Melatonin on Pain, Sleep and Neurodegeneration Serhat AKIN, Çäla ¿¿¿MAN Chapter 26 Tools for Evaluating Sleep-Headache Interactions Mona NADA Chapter 27 Information Classification: General Biomarkers in Neurodegeneration: CSF, Imaging and Polysomnography Ozan DÖRTKOL, Arife Çimen ATALAR Chapter 28 Differential Diagnosis: Is it a Primary Disorder or Neurodegeneration? Burak YILDIZ, Ahmet EVL¿CE Chapter 29 Pharmacological Interventions: Melatonin, Antiseizures, and CGRP Antagonists Nesrin ERG¿N Chapter 30 Non-Pharmacological Approaches: CBT, Light Therapy, and Neurostimulation Tuba TANYEL SARAÇO¿LU, Derya ULUDÜZ Chapter 31 Challenges in the Treatment of Comorbid Conditions Zeynep SELCAN ¿ANLI, Wael MOHAMED Chapter 32 Sleep Hygiene and Dietary Modifications Mansoureh TOGHA, Soodeh RAZEGHI Chapter 33 Exercise, Stress Management and Cognitive Training Merve CEREN AKGÖR, Arão Belitardo de OLIVEIRA Chapter 34 Challenges and Opportunities for Global Sleep Medicine Francis FEZEU Chapter 35 Case Studies and Clinical Vignettes: Alzheimer's Disease with Chronic Migraine and Insomnia Zeynep Z¿RO¿LU, Esra ACIMAN DEM¿REL Information Classification: General Chapter 36 Case Studies and Clinical Vignettes: Parkinson's Disease with REM Sleep Behavior Disorder and Tension-Type Headache Aygül GÜNE¿, Onur Serdar GENÇLER Chapter 37 Case Studies and Clinical Vignettes: Sleep Apnea and Chronic Migraine with and without Medication-Overuse Headache Michelle BRAVO, Angeliki VGONTZAS, Alexandra COCORES, Alberto RAMOS, Teshamae S. MONTEITH Chapter 38 Advances in Diagnostic Discovery: Wearable Technology Sümeyye Yasemin ÇALLI, Yämur Sever F¿DAN, Füsun MAYDA DOMAÇ Chapter 39 Emergent Therapies Targeting Shared Pathways ¿ennur DEL¿BA¿ KATI Chapter 40 Integrating Precision Medicine into Clinical Practice Burcu KARPUZ SEREN