Preface xxiii
Part I: Fundamentals of 3D Printing in Pharmaceuticals 1
1 Introduction to 3D Printing in Pharmaceuticals 3
Sachin Joshi, Priya Jindal, Balak Das Kurmi, Manish Kumar and Kuldeep Vinchurkar
1.1 Introduction 4
1.2 Categories of 3D Printing Methods in Drug Delivery 6
1.3 3D printing Materials Utilized for Pharmaceuticals 9
1.4 Drug Delivery Technology in 3D Printing 11
1.5 Various Applications of 3D Printing 14
1.6 Possibilities and Difficulties Associated with Applying 3D Printing to Medicine 17
1.7 Conclusion and Recommendations for the Future 18
2 Fundamentals of Pharmaceutical 3D Printing 23
Hardik Rana, Mansi Dholakia, Vimal Patel, Saloni Dalwadi and Kuldeep Vinchurkar
2.1 Design to Object 24
2.2 Types of 3D Printing Material 63
2.3 Key Components of a 3D Printer 68
2.4 Software and Tools for 3D Printing 82
3 Advancements and Applications of 3D Bioprinting in Pharmaceutical Research: A Comprehensive Review 105
Amar Deshpande, Shilpa S. Borkar, Ketki Bhatt, Koustubha S. Pachkor, Satish Polshetttiwar and Jagdish Baheti
3.1 Introduction 106
3.2 Classification of 3D Bioprinting (3DBP) 107
3.3 Methods for Bioprinting 108
3.4 Inkjet-Based Bioprinting 111
3.5 Bioprinting Material 115
3.6 Applications 118
3.7 Advantages 119
3.8 Disadvantages 119
3.9 Future Prospective 120
3.10 Conclusion 120
4 3D Printing of Solid Dosage Forms 129
Ashwin Kuchekar, Prajakta Wagh, Harshavardhan Karnik and Ashwini Gawade
4.1 Introduction 130
4.2 Types of 3D Printing Technologies for Solid Dosage Forms 133
4.3 Materials Used in 3D Printing of Solid Dosage Forms 139
4.4 Design and Formulation Considerations in 3D Printing of Oral Solid Dosage Forms 142
4.5 Manufacturing Process 144
4.6 Quality Control and Regulatory Aspects 151
4.7 Case Studies and Applications 160
4.8 Advantages of 3D Printing in Healthcare Industry 163
4.9 Future Directions and Innovations in 3D Printing for Pharmaceuticals 165
4.10 Conclusion 167
Part II: Applications of 3D Printing in Pharmaceuticals 175
5 3D Printing of Controlled Release Systems 177
Chirag Jain, Shubham Kumar, Shreya Kaul, Manisha Pandey, Bapi Gorain, Najwa Mohamad and Neha Jain
5.1 Introduction 178
5.2 Technologies Utilized in 3D Printing 181
5.3 Recent Advances in 3D Printing of Controlled Release Systems 183
5.4 Technology Lab to Market 193
5.5 Conclusion 200
6 Fabrication of Implants and Medical Devices via Three-Dimensional Printing Technology 207
Ruchira Srivastava and Ayushi Thakur
6.1 Introduction 207
6.2 Various Categories of Three-Dimensional Printing Techniques 209
6.3 Applications in Medical Devices and Implants 217
6.4 Advantages: 3D Printing in Medical Applications 222
6.5 Challenges and Considerations of 3D Printing in Medical Applications 223
6.6 Conclusion 224
7 3D Printing in Drug Delivery System 229
Satish Polshettiwar, Shrikant Dargude, Pranali Polshettiwar, Saloni Ghodmare, Swati Jagdale and Kuldeep Vinchurkar
7.1 Introduction 230
7.2 3D-Printed Drug Delivery System 232
7.3 Applications of 3D Printing in Drug Delivery 245
7.4 Challenges and Limitations 247
7.5 Conclusion 248
8 3D Bioprinting in Pharmaceutical Research 257
Vijaya Padwal, Sachin Kothawade, Sandesh Bole and Kuldeep Vinchurkar
8.1 Introduction 258
8.2 Significance in Pharmaceutical Research 259
8.3 Objectives and Structure 261
8.4 Principles of 3D Bioprinting 262
8.5 Types of Bioprinting 264
8.6 Types of 3D Bioprinters 269
8.7 Materials Used for Bioprinting 273
8.8 Drug Evaluation 279
8.9 Drug Delivery 280
8.10 Customization of Patient-Specific Medications/Personalized Medicine 282
8.11 3D Printing Method and Techniques 283
8.12 Applications of 3D Printing in Personalized Medicines 284
8.13 Conclusion 286
9 Case Studies and Success Stories of Companies Leveraging 3D Printing Technology 295
Debarshi Kar Mahapatra, Kuldeep Vinchurkar and Dinesh Kumar Mishra
9.1 Introduction 296
9.2 Technology and Future 298
9.3 Case and Success Studies of Companies Leveraging 3D Printing Technology 300
9.4 Conclusion 319
Part III: Regulatory, Commercial, and Sustainability Aspects 323
10 Regulatory and Quality Considerations in 3D Printing Technology 325
Chaitanay Vinayak Narayan, Manasvi Saini, Swati Verma, Ajmer Singh Grewal and Kunal Nepali
10.1 Introduction 326
10.2 Patient Safety Concerns with 3D-Printed Medical Products 332
10.3 Legal and Regulatory Framework for 3D Printing of Medical Devices 332
10.4 Regulatory Standards for 3D-Printed Pharmaceuticals 336
10.5 Conclusion 339
11 Intellectual Property Issues in Pharmaceutical 3D Printing 345
Varalaxmi Sagili, Sarad Pawar Naik Bukke, Shanmugam Vippamakula, Buyinza Nichola and Kabali Moses
12 Economic and Commercial Aspects of 3D Printing Technology 365
Sarad Pawar Naik Bukke, Varalaxmi Sagili, Shanmugam Vippamakula, Allan Amooti Ahikiriza and Muhamad Mustafa Mundu
12.1 Overview of 3D Printing Technologies Used in Pharmaceutical Industries 367
12.2 3D Printing Technologies Used in the Manufacture of Drug Delivery Systems in the Pharmaceutical Industry 372
12.3 Development and Commercialization of 3D Printing Technologies in Pharmaceuticals According to Patient Preferences 375
12.4 Current Scenario in Large-Scale Manufacturing of 3D Printing Pharmaceuticals 378
12.5 3D Printing in Personalized Medicine 379
12.6 Future Impacts of 3D Printing on the Pharmaceutical Industrial Sector 380
13 Environment Impact and Sustainability of 3D Printing in Pharmaceuticals 383
Buyinza Nicholas, Varalaxmi Sagili, Sarad Pawar Naik Bukke, Allan Amooti Ahikiriza and Kasolo Daniel
13.1 Introduction 384
13.2 Additives Used in 3D Printing 385
13.3 3D Printing Method and Its Impact on the Environment 390
13.4 Index of Greenness Assessment of Printed Pharmaceuticals 391
13.5 Life Cycle Analysis (LCA) of 3D Printing 393
13.6 Substitution of Energy Sources 394
13.7 Sustainability in 3D Printing 394
13.8 Limitations and Future Perspectives 394
13.9 Conclusion 395
Part IV: Challenges Future Perspectives 397
14 Challenges and Ethical Considerations in 3D Printing Technology 399
Mallamma T., Prakash Goudanavar, Pranav Nayak, Moumita Banerjee and Kuldeep Vinchurkar
14.1 Introduction 400
14.2 Technical Challenges in 3D Printing: Material Limitations 401
14.3 Technical Challenges in 3D Printing: Scalability 404
14.4 Case Studies and Applications 407
14.5 Economic and Business Challenges of 3D Printing Technology: Cost Considerations 408
14.6 Economic and Business Challenges of 3D Printing Technology: Market Adoption 409
14.7 Economic and Business Challenges 411
14.8 Ethical Considerations 413
14.9 Ethical Considerations: Accessibility and Equality in 3D Printing Technology 416
14.10 Legal and Social Challenges in 3D Printing Technology 418
14.11 Healthcare: Case Studies on the Use of 3D Printing in Healthcare 422
14.12 Challenges and Ethical Considerations in 3D Printing Technology: Aerospace and Defense 424
14.13 Challenges and Ethical Considerations in 3D Printing Technology: Consumer Goods 426
14.14 Challenges and Ethical Considerations in 3D Printing Technology: Future Directions and Recommendations 428
14.15 Ethical Challenges in Clinical Applications 430
14.16 Future Recommendations for Policy and Practice 432
14.17 Conclusion 434
15 Future Directions and Emerging Trends in 3D Printing Integrating with Artificial Intelligence and Machine Learning 443
Sutapa Biswas Majee, Sudarshan Singh, Ushasi Das, Dhruti Avlani, Rachayeeta Bera, Shourya Karmakar and Kuldeep Vinchurkar
15.1 Introduction 444
15.2 Basic Concepts of 3D Printing and 3D Bioprinting 445
15.3 Trends in Progress in 3DP and 3DBP 449
15.4 Need for Artificial Intelligence and Machine Learning in 3D Printing Technology in Pharmaceutical and Healthcare Industries 451
15.5 Artificial Intelligence and Machine Learning: Brief Overview 452
15.6 Future Prospects and Emerging Trends in AI-Driven 3D Printing 468
15.7 Conclusion 471
References 472
Index 489
