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Produktbild: Targeting Protein-Protein Interactions for Drug Discovery
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Targeting Protein-Protein Interactions for Drug Discovery

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

12.11.2025

Abbildungen

35

Herausgeber

Jian Zhang

Verlag

Wiley-VCH

Seitenzahl

432

Maße (L/B/H)

24,5/17,8/3 cm

Gewicht

666 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-35360-6

Beschreibung

Portrait

Jian Zhang received a BM degree in Pharmacology in 2002 from Peking University and a PhD in 2007 from Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Then he moved to the University of Michigan to carry out postdoctoral research in Prof. Shaomeng Wang's group. In 2009, he joined Shanghai Jiao Tong University, School of Medicine, where he is a distinguished professor and doctoral supervisor. Currently, he is also the director of the Medicinal Bioinformatics Center. His fields of research include first-in-class drug design and chemical biology mainly pertaining to protein-protein interactions and allostery and their application in drug discovery.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

12.11.2025

Abbildungen

35

Herausgeber

Jian Zhang

Verlag

Wiley-VCH

Seitenzahl

432

Maße (L/B/H)

24,5/17,8/3 cm

Gewicht

666 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-3-527-35360-6

Herstelleradresse

Wiley-VCH GmbH
Boschstraße 12
69469 Weinheim
DE

Email: GPSR Kontakt

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Die Leseprobe wird geladen.
  • Produktbild: Targeting Protein-Protein Interactions for Drug Discovery
  • Chapter 1: Exploring Protein-Protein Interactions: Concepts, Methods, and Implications

    1.1 General concepts of protein-protein interactions

    1.2 Functional significance of protein-protein interactions

    1.3 Methods for analyzing protein-protein interactions

    1.4 Implications of the basic research on protein-protein interactions

    1.5 Conclusions and perspectives

     

    Chapter 2: Overview of drug discovery targeting PPI systems

    2.1 Introduction

    2.2 Fundamentals of Protein-Protein Interactions

    2.3 Challenges in Targeting PPI Systems

    2.4 Approaches in Drug Discovery Targeting PPI Systems

    2.5 Case Studies and Success Stories

    2.6 Conclusion

     

    Chapter 3: Fluorescence Resonance Energy Transfer Technology and its Applications

    3.1 Introduction

    3.2 Mechanism of FRET

    3.3 Applications of FRET

    3.4 Advantages and Limitations

    3.5 Recent Advances

    3.6 Conclusion

     

    Chapter 4: Dissect Protein Interactions Using Mass Spectrometry

    4.1 Introduction

    4.2 Affinity purification coupled with mass spectrometry (AP-MS)

    4.3 Proximity labeling

    4.4 Cross-linking mass spectrometry (XL-MS)

    4.5 Co-fractionation coupled with mass spectrometry (CF-MS)

    4.6 Thermal proximity coaggregation (TPCA)

    4.7 Limited proteolysis?mass spectrometry (LiP?MS)

    4.8 Conclusion and outlook

     

    Chapter 5: Detection of protein-protein interactions in situ via proximity ligation assay

    5.1 Introduction

    5.2 Implementations of proximity ligation assay

    5.3 Applications of PLA for detecting protein-protein interactions

    5.4 Conclusions and outlooks

     

    Chapter 6: The Application of Surface Plasmon Resonance in the Characterization of Protein-Protein Interactions

    6.1 Introduction

    6.2. Applications of SPR assay in PPI Characterization

    6.3. Advantages and Limitations of SPR Application for PPIs

    6.4. Future Directions

     

    Chapter 7: Computational methods for protein-protein interactions

    7.1. Introduction

    7.2. Protein-protein docking

    7.3. End-to-end structure prediction

    7.4. CAPRI experiments

    7.5. Challenges and Future directions

     

    Chapter 8: Foldamers as Inhibitors of Aberrant Protein-Protein Interactions

    8.1 Introduction

    8.2 The Evolution of Hamilton?s Oligopyridylamides

    8.3 Limitations of a Tedious Synthetic Route

    8.4 OPs as Antagonists of Neurodegeneration

    8.5 OPs Inhibit HIV Infection

    8.6 OPs Targeting Type II Diabetes

    8.7 OPs Targeting and Reactivating Mutant Protein in Cancer

    8.8 Novel Synthesis of OPs and Alzheimer?s Disease

    8.9 2D-FAST

    8.10 OQ Foldamers - Structure and Discovery

    8.11 Synthesis of OQ Foldamers

    8.12 OQs as Modulators of Type II Diabetes-Related aPPIs

    8.13 Mechanistic Insights to OQ Manipulation of aPPIs

    8.14 Chemical Diversity and Structure Modulate Efficacy of Oqs

    8.15 Modulation of Alzheimer?s Disease-Related Aß

    8.16 OQs for the Modulation of Synucleinopathies

    8.17 Epilogue

     

    Chapter 9: Application of Sulfonyl-¿-AApeptides for PPI Drug Discovery

    9.1 Introduction to the Structure of Sulfonyl-¿-AA-peptides

    9.2 The Applications of Sulfonyl-¿-AA-peptides

    9.3 Future Directions/Conclusions

     

    Chapter 10: Introduction of the Application of Stapled Peptides in Protein-Protein Interactions Drug Discovery and their Successful Examples

    10.1. Introduction

    10.2. Stapled Peptides: Structure Features and Benefits

    10.3. Successful Applications of Stapled Peptides in Drug Discovery

    10.4. Challenges and Limitations

    10.5. Future Directions

     

    Chapter 11: Cyclic peptides for PPI drug discovery

    11.1. a-helix cyclic peptides (stapled peptides)

    11.2. ß-hairpin cyclic peptides

    11.3. Macrocyclic peptides

    11.4. Summary and outlook

     

    Chapter 12: Small molecule inhibitors targeting protein-protein interactions in the BCL protein

    12.1 Introduction

    12.2 Inhibitors of BCL-2 family antiapoptotic proteins

    12.3 Inhibitors of ß-catenin/BCL9

    12.4 Targeting BCL-6 small molecule inhibitors

    12.5. BCL-3 inhibitors

    12.6. BCL-10 inhibitors

    12.7. Summary

     

    Chapter 13: Molecular Glues as Activators for PPI

    13.1 Introduction

    13.2 Molecular Glues as orthosteric PPI stabilizers/activators

    13.3 Methods for Molecular Glue Discovery

    13.4 Conclusions and Outlook

     

    Chapter 14: Targeting APC?Asef Protein-Protein Interaction for Drug Discovery in Colorectal Cancer Therapy

    14.1. Introduction

    14.2. Structural insights into APC?Asef interaction

    14.3. Current APC?Asef inhibitor

    14.4. A More Sensitive FP Method for Identifying Highly Active APC?Asef Inhibitors

    14.5. Conclusions and Outlook

     

    Chapter 15: Computational methods applied to drug discovery of protein-protein interaction systems

    15.1 Introduction

    15.2 Computational methods for PPI prediction

    15.3 Conclusions and outlook