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Produktbild: Sweet Biochemistry

Sweet Biochemistry Remembering Structures, Cycles, and Pathways by Mnemonics

138,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

25.07.2023

Verlag

Elsevier

Seitenzahl

242

Maße (L/B/H)

15,2/22,9/1,8 cm

Gewicht

450 g

Auflage

2nd edition

Sprache

Englisch

ISBN

978-0-443-15348-8

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

25.07.2023

Verlag

Elsevier

Seitenzahl

242

Maße (L/B/H)

15,2/22,9/1,8 cm

Gewicht

450 g

Auflage

2nd edition

Sprache

Englisch

ISBN

978-0-443-15348-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Sweet Biochemistry

  • List of figures
    List of tables

    Preface
    Acknowledgements

    1. Glycolysis
    Microview
    Importance of glucose phosphorylation
    Role of magnesium for kinases
    Critical isomerisation to fructose
    Second phosphorylation
    Reason of DHAP conversion to Gly-3-P?
    Conversion of Gly-3-P to 1,3-bisphosphoglycerate
    Reaction of phosphoglycerate kinase: the heroic step
    PG isomerises to 2-PG: the role
    Importance of enolase reaction

    2. Citric acid cycle
    First have a look at the quick view of pathway
    Now let us observe the reactions in detail

    3. Electron transport chain
    Microview
    The special electron transporters: NADH and FADH2
    The story of electron transport chain
    What relates to electron transport chain in the story?

    4. Beta oxidation of fatty acids
    Importance of beta oxidation of fatty acids
    Carnitine: prominent molecule of beta oxidation

    5. Fatty acid biosynthesis
    Traditional recap
    Microview
    Relation of beta oxidation and synthesis of fatty acids synthesis

    6. Cholesterol structure
    Role of cholesterol
    Lipid rafts and cholesterol
    What relates to cholesterol in honeycomb house?

    7. Cholesterol synthesis
    Traditional recap
    Microview
    First enzyme thiolase
    3-Hydroxy-3-methylglutaryl-CoA synthase
    3-Hydroxy-3-methylglutaryl-CoA reductase
    Story of queen bee's honeycomb house

    8. Haem synthesis
    Rate-limiting step of haem synthesis: aminolevulinic acid formation
    Regulation of aminolevulinic acid synthase
    Aminolevulinic acid synthase activity in liver can be induced by steroids and some drugs by promoting ALAS1 gene expression

    9. Porphyrias
    Traditional recap
    Manifestations of porphyria
    Why photosensitivity and neuropsychiatric symptoms are observed in porphyrias?
    Pain is reported by patients with porphyrias even within minutes of visible light or neon light exposure
    Neuropsychiatric features
    High ALAS1 activity may deplete pyridoxal phosphate, adding further to secondary sensory axonal neuropathy

    10. Urea cycle
    Carbamoyl phosphate synthetase 1: an unique enzyme
    Are there other modulators also for carbamoyl phosphate synthetase 1?

    11. Urea cycle disorders
    But why ammonia is so toxic to brain?

    12. Glycogen storage disorders
    Glycogen storage diseases
    Mechanisms for features of glycogen storage disorders
    Story mnemonic of glycogen storage disorders

    13. Mucopolysaccharidoses
    Hurler disease
    Scheie syndrome: Mucopolysaccharidoses I
    Hunter syndrome: Mucopolysaccharidoses II
    Sanfilippo syndrome: Mucopolysaccharidoses III
    Morquio syndrome: Mucopolysaccharidoses IV
    MaroteauxLamy syndrome: Mucopolysaccharidoses VI
    Sly syndrome: Mucopolysaccharidoses VII

    14. Lipid storage disorders/sphingolipidoses
    Tay-Sach's disease and Sandoff's disease
    Gaucher disease
    NiemannPick disease
    Farber's disease
    Fabry's disease
    Metachromatic leukodystrophy

    15. Ceramide structure and derivatives
    What are ceramides doing in our body

    16. Prostaglandin synthesis
    Biological actions of prostaglandins
    Cyclooxygenase is the controller of rate-limiting step

    17. Purine structure
    Chemically
    Here are some interesting purines

    18. Purine synthesis de novo
    A brief view of reactions
    Amido phosphoribosyl transferase (Atase) rate-limiting
    enzyme with a unique ammonia channel
    Interesting regulation of purines

    19. Pyrimidine structure-2
    Uracil
    Thymine
    Cytosine

    20. Pyrimidine de novo .

    21. DNA structure and DNA replication
    Alternative DNA structures
    Here is a brief summary of steps of DNA replication

    22. Differences in eukaryotic and prokaryotic replication

    23. Transcription
    Let us see the steps of transcription

    24. Translation
    Chain termination

    25. Inhibitors of translation
    Antibiotics and the mechanism of action
    Toxins that disturb protein synthesis
    Lectins

    26. Operon
    The lac Operon

    27. Various types of RNA
    Messenger RNA
    Small-nuclear RNA
    MicroRNA
    Small-interfering RNA
    Ribozyme

    28. Antibody

    29. Class switching
    When is class switching required?
    Mechanism of class switching

    30. Antigen
    Hapten
    Superantigens
    Neoantigens
    Autoantigen
    Adjuvants

    31. Major histocompatibility complex
    The categorisation of human leucocyte antigen forms three classes I, II and III

    32. Vaccines
    Whole pathogen vaccines
    Subunit vaccine
    Recombinant protein vaccine
    Toxoid vaccine
    Conjugate vaccine
    Virus-like particles
    Outer membrane vesicle vaccines
    Nucleic acid vaccines
    Viral-vectored vaccines

    Exercises
    Further reading
    Index