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Precision Medicine in Neurodegenerative Disorders Part I Volume 192

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Beschreibung

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual...

Beschreibung

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology deals with the "Why" in the approach to slow the progression of accelerated brain aging. This volume is intended to provide a scholarly background on the framework, basic science and conceptual pitfalls related to disease-modifying efforts in Parkinson's, Alzheimer's and other neurodegenerative disorders. Among topics covered are different models of precision medicine, the lumping-versus-splitting tension in biomarker development and therapeutics, and the rationale for replacing the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases with the divergence of a systems biology approach to human diseases.

Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the highest level of personalized medicine.

Portrait

Dr. Alberto Espay is Professor and Endowed Chair of the James J. and Joan A. Gardner Center for Parkinson's disease at the University of Cincinnati. He has published over 300 peer-reviewed research articles and 8 books, including Common Movement Disorders Pitfalls, which received the Highly Commended BMA Medical Book Award in 2013 and Brain Fables, the Hidden History of Neurodegenerative Diseases and a Blueprint to Conquer them, coauthored with Parkinson patient and advocate Benjamin Stecher, selected by the Association of American Publishers for the PROSE Award honoring the best scholarly work in Neuroscience published in 2020. He has served as Chair of the Movement Disorders Section of the American Academy of Neurology, Associate Editor of the Movement Disorders journal, and on the Executive Committee of the Parkinson Study Group. Among other honors, he has received the Cincinnati Business Courier's Health Care Hero award, the Spanish Society of Neurology's Cotzias award, and honorary membership in the Mexican Academy of Neurology. He currently serves as President-Elect of the Pan-American Section of the International Parkinson and Movement Disorders Society.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

28.06.2023

Herausgeber Alberto J. Espay
Verlag Elsevier Science & Technology

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

28.06.2023

Herausgeber Alberto J. Espay
Verlag Elsevier Science & Technology
Seitenzahl

288

Maße (L/B/H)

26,4/19,3/2 cm

Gewicht

794 g

Sprache

Englisch

ISBN

978-0-323-85538-9

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Precision Medicine in Neurodegenerative Disorders
  • Part 1 Conceptual Framework
    1. The definition of precision medicine in neurodegenerative disorders and the one disease-many-diseases tension
    2. Models of precision medicine for neurodegeneration
    3. Pathology vs pathogenesis: Rationale and pitfalls in the clinicopathology model of neurodegeneration
    4. Mixed pathology as a rule, not exception: Time to reconsider disease nosology?
    5. Neurodegenerative disorders: From clinicopathology convergence to systems biology divergence
    6. The emergence of genotypic divergence and future precision medicine applications
    7. Lessons from other fields of medicine, Part 1: Breast cancer
    8. Lessons from other fields of medicine, Part 2: Cystic fibrosis
    9. Lessons learned from evolving frameworks in adult glioblastoma

    Part 2 Pitfalls in Definitions, Cohorts, and Measures of Progression
    10. Finding the falsification threshold of the toxic proteinopathy hypothesis in neurodegeneration
    11. The theoretical problems of "prodrome? and "phenoconversion? in neurodegeneration
    12. The dilemma between milestones of progression vs. clinical scales in Parkinson disease
    13. Biomarkers of diagnosis, prognosis, pathogenesis, response to therapy: Convergence or divergence? Lessons from Alzheimer Disease and synucleinopathies
    14. Challenges in the study of individuals at risk for Parkinson disease
    15. The challenging quest of neuroimaging: From clinical to molecular-based subtyping of Parkinson disease and atypical parkinsonisms