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  • Produktbild: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
  • Produktbild: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
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Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

08.06.2021

Abbildungen

XVII, 453 p. 109 illus., 91 illus. in color.

Herausgeber

Gus R. Rosania + weitere

Verlag

Springer Us

Seitenzahl

453

Maße (L/B/H)

25,4/17,8/2,6 cm

Gewicht

880 g

Sprache

Englisch

ISBN

978-1-07-161252-1

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

08.06.2021

Abbildungen

XVII, 453 p. 109 illus., 91 illus. in color.

Herausgeber

Verlag

Springer Us

Seitenzahl

453

Maße (L/B/H)

25,4/17,8/2,6 cm

Gewicht

880 g

Sprache

Englisch

ISBN

978-1-07-161252-1

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: ProductSafety@springernature.com

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  • Produktbild: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
  • Produktbild: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery

  • Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient.- Kinetic Design for Establishing Long Term Stationary Cytosol Concentrations during Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane and Kinetically Identifying Drug Uptake Transporters.- In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug-Drug Interactions.- Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration.- Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes.- Quantification of Intracellular Drug Aggregates and Precipitates.- Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulations.- Using an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomembranes, with Particular Reference to Fluorescent Imaging Probes.- Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging.- Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics.- Intracellular Targeting of Cyclotides for Therapeutic Applications.- Cellular Trafficking of Monoclonal and Bispecific Antibodies.- Quantitative Drug Target Imaging Using Paired-Agent Principles.- Quantitative Determination of Intracellular Bond Cleavage.- Development and Application of a Single Cell-Level PK-PD Model for ADCs.- Contribution of Non-Target Cells to the Disposition, Antitumor Activity, and Antigen-Independent Toxicity of Antibody Drug-Conjugates.- Tracking siRNA-Nanocarrier Assembly and Disassembly Using FRET.- Sub-Cellular Drug Depots as Reservoirs for Small Molecule Drugs.