• Produktbild: Global Epidemiology of Cancer
  • Produktbild: Global Epidemiology of Cancer

Global Epidemiology of Cancer

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.04.2022

Verlag

John Wiley & Sons Inc

Seitenzahl

666

Maße (L/B/H)

25,4/17,8/3,7 cm

Gewicht

1363 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-81744-4

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.04.2022

Verlag

John Wiley & Sons Inc

Seitenzahl

666

Maße (L/B/H)

25,4/17,8/3,7 cm

Gewicht

1363 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-81744-4

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Global Epidemiology of Cancer
  • Produktbild: Global Epidemiology of Cancer
  • About the Authors xv

    Preface xvii

    Acknowledgments xix

    Part I Introduction 1

    1 Pathogenesis of Cancer 3

    The Origin of Cancer 3

    Cancer Biology 7

    Genetics and Cancer 9

    Cell Division 11

    Cell Cycle 12

    Carcinogenesis 14

    Mutation and Cancer 16

    Metastasis 17

    Key Terms 20

    Bibliography 20

    2 Global Epidemiology of Cancer 23

    Incidence 23

    Prevalence 24

    Survival 26

    Distribution of Cancer by Gender, Race, and Age 28

    Global Burden of Cancer 29

    Global Trends in Cancer 31

    Global Prevalence of Cancer 32

    Global Incidence and Mortality 32

    Mortality due to Cancer in the United States 33

    Risk Factors for Cancer Development 34

    Years of Life Lost 36

    Disability-Adjusted Life Years 36

    Global Cancer Prevention 36

    Key Terms 38

    Bibliography 38

    Part II Cancers of the Body Systems 41

    3 Brain and Spine Tumors 43

    Benign / Low Grade Tumors 43

    Meningioma 44

    Hemangioma 48

    Neurofibroma 51

    Schwannoma 53

    Astrocytoma 55

    Pituitary Adenoma 59

    Malignant Tumors 62

    Pituitary Carcinoma 63

    Pineoblastoma 65

    Anaplastic Oligodendroglioma 67

    Anaplastic Ependymoma 69

    Anaplastic Astrocytoma 70

    Embryonal Carcinoma 73

    Choriocarcinoma 74

    Teratoma 75

    Metastatic Tumors 77

    Key Terms 80

    Bibliography 81

    4 Endocrine Tumors 85

    Thyroid Adenoma 85

    Thyroid Cancers 87

    Papillary Carcinoma 87

    Follicular Carcinoma 91

    Medullary Carcinoma 93

    Anaplastic Thyroid Carcinoma 96

    Parathyroid Tumors 98

    Adenoma 98

    Carcinoma 100

    Thymus Tumors 102

    Thymoma 102

    Thymolipoma 105

    Thymoliposarcoma 106

    Adrenal Tumors 108

    Adenoma of the Cortex 108

    Carcinoma of the Cortex 110

    Pheochromocytoma 114

    Neuroblastoma 116

    Multiple Endocrine Neoplasia 119

    Key Terms 124

    Bibliography 124

    5 Respiratory Tumors 127

    Nasopharyngeal Tumors 127

    Nasopharyngeal Angiofibroma 127

    Nasopharyngeal Hemangioma 128

    Nasopharyngeal Carcinoma 128

    Laryngeal Cancer 131

    Lung Cancer 135

    Bronchial Carcinoma 148

    Carcinoid Tumors 151

    Mesothelioma 155

    Key Terms 161

    Bibliography 161

    6 Digestive Tumors 165

    Oral and Oropharyngeal Cancer 165

    Esophageal Cancer 171

    Stomach Cancer 176

    Small-Bowel Tumors 180

    Familial Adenomatous Polyposis 183

    Colorectal Tumors 186

    Anorectal Cancer 191

    Pancreatic Cancer 194

    Liver and Biliary Tract Cancers 198

    Hepatocellular Carcinoma 198

    Liver Metastases 201

    Gallbladder Cancer 204

    Key Terms 208

    Bibliography 208

    7 Lymphatic and Blood Cancer 211

    Lymphomas 211

    Non-Hodgkin's Lymphoma 211

    Hodgkin's Lymphoma 216

    Multiple Myeloma 222

    Leukemias 225

    Acute Lymphoblastic Leukemia 226

    Acute Myeloid Leukemia 230

    Chronic Lymphocytic Leukemia 234

    Chronic Myeloid Leukemia 237

    Key Terms 239

    Bibliography 240

    8 Male Reproductive Tumors 243

    Benign Prostatic Hyperplasia 243

    Prostate Cancer 248

    Testicular Cancer 256

    Penile Cancer 261

    Key Terms 264

    Bibliography 265

    9 Female Reproductive Tumors 269

    Benign Breast Tumors 269

    Breast Cancer 272

    Benign Ovarian Masses 286

    Ovarian Cancer 290

    Uterine Fibroids 296

    Endometrial Cancer 300

    Uterine Sarcoma 306

    Choriocarcinoma 309

    Cervical Polyps 311

    Cervical Cancer 312

    Vaginal and Vulvar Cancer 318

    Key Terms 321

    Bibliography 322

    10 Skin Tumors 327

    Moles 327

    Dermatofibromas 331

    Infantile Hemangiomas 332

    Lipoma and Liposarcoma 335

    Keloids 337

    Melanoma 338

    Basal Cell Carcinoma 343

    Squamous Cell Carcinoma 347

    Bowen Disease 350

    Merkel Cell Skin Cancer 353

    Kaposi Sarcoma 355

    Key Terms 359

    Bibliography 359

    11 Bone Tumors 363

    Benign Bone Tumors 363

    Multiple Myeloma 368

    Osteosarcoma 368

    Chondrosarcoma 373

    Ewing Sarcoma 376

    Giant Cell Tumor of Bone 379

    Metastatic Bone Tumors 383

    Key Terms 386

    Bibliography 386

    12 Kidney and Urinary Bladder Tumors 391

    Adenoma 391

    Angiomyolipoma 393

    Renal Cell Carcinoma 395

    Renal Sarcoma 400

    Wilms' Tumor 402

    Metastatic Tumors 406

    Urinary Bladder Cancer 408

    Transitional Cell Carcinoma 408

    Squamous Cell Carcinoma 411

    Adenocarcinoma 413

    Key Terms 415

    Bibliography 415

    13 Diagnostic Procedures 421

    Traditional X-rays 421

    Computed Tomography 424

    Positron Emission Tomography 428

    Magnetic Resonance Imaging 431

    Doppler and Duplex Doppler Ultrasonography 434

    Transrectal Ultrasonography 436

    Mammography 436

    Nuclear Medicine 439

    Endoscopy 441

    Endoscopic Retrograde Cholangiopancreatography 444

    Biopsy 444

    Lumbar Puncture 445

    Hematology Tests 447

    Urinalysis 448

    Genetic Testing 450

    Key Terms 451

    Bibliography 452

    Part III Treatment of Cancers 455

    14 Surgical Oncology 457

    Biopsy Techniques 457

    Fine-Needle Aspiration 457

    Core-Needle Biopsy 459

    Open Biopsy 461

    Endoscopic Biopsies 462

    Cardiopulmonary Factors 462

    Hematologic Factors 463

    Gastrointestinal Factors 464

    Geriatric Factors 464

    Medications Affecting Surgery 467

    Anesthesia 468

    Resection 469

    Tumor Margins 469

    Sentinel Lymph Node Biopsy 470

    Minimally Invasive Procedures 470

    Emergent Surgery 472

    Key Terms 472

    Bibliography 473

    15 Radiation Therapy 475

    The Purpose of Radiation Therapy 476

    Radiobiology 476

    Cellular Response to Radiation 476

    The Cell Cycle and Radiosensitivity 477

    Cell Death 478

    Factors Affecting the Biology of Cancers 479

    Oxygen Effect 479

    Dose Rate 480

    Relative Biologic Effectiveness 480

    Radiosensitivity 480

    Apoptosis 480

    Linear Energy Transfer 481

    Fractionation 481

    Types of Radiation Therapy 483

    External Beam Radiation Therapy 483

    Stereotactic Radiosurgery 485

    Adaptive Planning 486

    Charged Particle External Beam Radiation Therapy 487

    Heavy Charged Particle External Beam Radiation Therapy 487

    Brachytherapy 487

    Radionuclide Therapy 489

    Intraoperative Radiotherapy 489

    Combined-Modality Therapy 489

    Hyperthermia 490

    Accidental Radiation Exposure 492

    Acute Radiation Syndrome 493

    Cutaneous Syndrome 493

    Gastrointestinal Syndrome 493

    Hematopoietic Syndrome 493

    Cerebrovascular Syndrome 493

    Radiation on the Embryo and Fetus 494

    Radiation and Malignancies 494

    Special Populations 495

    Pregnant Women 495

    Children 495

    Elderly 495

    Key Terms 495

    Bibliography 495

    16 Chemotherapy 499

    Pharmacology of Chemotherapeutic Drugs 500

    Principles of Pharmacokinetics 500

    Pharmacogenomics 502

    Drug Interactions with Chemotherapy 503

    Antineoplastic Drugs 503

    Classic Alkylating Agents 505

    Platinum Analogs 507

    Miscellaneous Alkylating Agents 508

    Anthracycline Antibiotics 508

    Miscellaneous Antitumor Antibiotics 510

    Folate Antagonists 510

    Purine Analogs 512

    Pyrimidine Analogs 513

    Vinca Alkaloids 514

    Taxanes 515

    Hormonal Therapies 517

    Chemotherapy-Induced Adverse Effects 520

    Bone Marrow Suppression 520

    Anemia 520

    Insomnia 521

    Cognitive Dysfunction 522

    Fatigue 522

    Thrombocytopenia 522

    Neutropenia 523

    Tumor Lysis Syndrome 525

    Gastrointestinal Tract Toxicity 526

    Integumentary Toxicity 528

    Cardiotoxicity 529

    Neurotoxicity 531

    Pulmonary Toxicity 536

    Nephrotoxicity 538

    Hepatotoxicity 540

    Key Terms 542

    Bibliography 542

    17 Immunotherapy 545

    Immunology Overview 545

    Innate Immunity 545

    Adaptive Immunity 546

    Cytokines 546

    Antigen Presentation Cell 546

    Tumor Escape Mechanisms 547

    Interleukin-2 548

    Biological Activity 548

    Indications of Interleukin-2 549

    Interferons 550

    Bacillus Calmette-Guérin 551

    Cancer Vaccines 551

    Major Histocompatibility Complex 552

    Immunoadjuvants 553

    Human Papillomavirus 553

    Prostate Cancer 554

    Clinical Studies of New Vaccines 554

    Key Terms 556

    Bibliography 556

    18 Gene Therapy 559

    Gene Therapy Regulation 559

    Cancer Gene Therapy 560

    Cancer Gene Therapy Protocols 560

    Tumor-Directed Gene Therapy Protocols 560

    Suicide Gene Therapy 560

    Tumor-Suppressor Gene Therapy 561

    Antisense Oligonucleotides 561

    Oncolytic Viral Gene Therapy 562

    Active Immunotherapy 562

    Tumor-Infiltrating Lymphocytes 562

    Cytokine Genes 563

    DNA Vaccines 563

    Adoptive Immunotherapy 563

    Chimeric Receptors 564

    Tumor-Specific T Cells 565

    Pharmacogenetics and Pharmacogenomics 565

    Ethical, Social and Legal Issues 566

    Key Terms 569

    Bibliography 569

    Glossary 571

    Index 593