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Progranulin Methods and Protocols

Aus der Reihe Methods in Molecular Biology
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106,99 € UVP 120,99 €

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

10.12.2019

Abbildungen

XIII, 79 illus., 56 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Herausgeber

Andrew Bateman + weitere

Verlag

Springer Us

Seitenzahl

363

Maße (L/B/H)

25,4/17,8/2,1 cm

Gewicht

724 g

Auflage

Softcover reprint of the original 1st ed. 2018

Sprache

Englisch

ISBN

978-1-4939-9325-3

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

10.12.2019

Abbildungen

XIII, 79 illus., 56 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Herausgeber

Verlag

Springer Us

Seitenzahl

363

Maße (L/B/H)

25,4/17,8/2,1 cm

Gewicht

724 g

Auflage

Softcover reprint of the original 1st ed. 2018

Sprache

Englisch

ISBN

978-1-4939-9325-3

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Progranulin
  • Preface…Table of Contents…Contributing Authors…

    Part I Introduction

    1. A Brief Overview of Progranulin in Health and DiseaseAndrew Bateman, Siu Tim Cheung, and Hugh P.J. Bennett

    Part II Analytical and In Vitro Methods for the Study of Progranulin Biology

    2. Chromatographic Methods for the Purification of Granulin PeptidesAndrew Bateman, Babykumari Chitramuthu, and Hugh P.J. Bennett

    3. Methods for Expression and Purification of Biologically Active Recombinant ProgranulinChun Yu Zhao and Andrew Bateman

    4. Large-Scale Generation of Recombinant Granulin Peptides in E. coliDmitri Tolkachev

    5. Nuclear Magnetic Resonance Spectroscopy in Analysis of Granulin Three-Dimensional Structure and Cysteine BridgingDmitri Tolkatchev

    6. Data Mining: Applying the AD&FTD Mutation Database to ProgranulinMarc Cruts and Christine Van Broeckhoven

    Part III Methods to Investigate the Role of Prgranulin in Cancer

    7. Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human DiseasesGinette Serrero and David Hicks

    8. Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic BiomarkerGinette Serrero and David Hicks

    9. Analysis of Progranulin-Mediated Akt and MAPK ActivationShi-Qiong Xu, Simone Buraschi, Ryuta Tanimoto, Manuela Stefanello, Antonio Belfiore, Renato V. Iozzo, and Andrea Morrione

    10. Mouse Monoclonal Antibodies Against Progranulin (PGRN/GEP) as Therapeutics in Preclinical Cancer ModelsChi Wai Yip, Phyllis F.Y. Cheung, Nicholas C.L. Wong, Sze Wai Fung, and Siu Tim Cheung

    11. Methods to Analyze the Role of Progranulin (PGRN/GEP) on Cancer Stem Cell FeaturesPhyllis F.Y. Cheung and Siu Tim Cheung

    12. Methods to Study the Role of Progranulin in the Tumor MicroenvironmentMoshe Elkabets and Samuel Brook

    Part IV Animal Models to Study the Role of Progragulin in Health and Disease

    13. Methods to Investigate the Molecular Basis of Progranulin Action on Neurons In Vivo using Caenorhabditis elegansJames Julian Doyle and J. Alex Parker

    14. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress ResponseTsung-Yuan Hsu, Victoria J. Butler, and Aimee W. Kao

    15. Application of Zebrafish and Knockdown Technology to Define Progranulin Neuronal FunctionBabykumari P. Chitramuthu and Hugh P.J. Bennett

    16. Methods to Investigate the Molecular Basis of Progranulin Actions on Brain and Behavior In Vivo Using Knockout MiceJan Boddaert, Hans Wils, and Samir Kumar-Singh

    17. Methods to Investigate the Protection Againts Neurodegenerative Disorders Provided by Progranulin Gene Transfer in the BrainJackalina M. Van Kampen

    18. The Interaction between Progranulin with Sortilin and the LysosomeXiaolai Zhou, Peter M. Sullivan, Daniel H. Paushter, and Fenghua Hu

    19. Methods to Study the Role of Progranulin in Preimplanatation Mouse Embryo DevelopmentLaura Diaz-Cueto, Fabian Arechavaleta-Velasco, and George L. Gerton

    20. Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-Inflammatory Activity of Progranulin in Inflammatory ArthritisJian-Iu Wei and Chuan-ju Liu

    21. Methods for Studying the Function of Progranulin in Atherosclerosis using Both Knockout Mice Models and In Vitro StudiesTohru Ohama, Ryota Kawase, Yasushi Sakata, and Shizuya Yamashita

    22. Methods to Investigate the Roles of Prgranulin in Angiogenesis Using In Vitro Strategies and Transgenic Mouse ModelsHuishi Toh, Eugene Daniels, and Andrew Bateman