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Produktbild: Principles of Bone Biology
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Principles of Bone Biology

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Beschreibung

Produktdetails

Einband

Paperback

Herausgeber

John P. Bilezikian + weitere

Verlag

Elsevier LTD, Oxford

Maße (B/H)

21,5/27,6 cm

Gewicht

5930 g

Auflage

4. Auflage

Sprache

Englisch

ISBN

978-0-12-814841-9

Beschreibung

Rezension

Review of the previous edition:
"Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine

Portrait

Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013).

Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.
Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA
Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Produktdetails

Einband

Paperback

Herausgeber

Verlag

Elsevier LTD, Oxford

Maße (B/H)

21,5/27,6 cm

Gewicht

5930 g

Auflage

4. Auflage

Sprache

Englisch

ISBN

978-0-12-814841-9

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  • Produktbild: Principles of Bone Biology
  • Volume 1
    Part I: Basic principles
    Section A Cell biology
    1. Molecular and cellular regulation of intramembranous and endochondral bone formation during embryogenesis
    2. Skeletal stem cells: tissue-specific stem/progenitor cells of cartilage, bone, stroma, and marrow adipocytes
    3. Bone marrow and the hematopoietic stem cell niche
    4. The osteoblast lineage: its actions and communication mechanisms
    5. Osteoclasts
    6. The osteocyte
    7. Transcriptional control of osteoblast differentiation and function
    8. Wnt signaling and bone cell activity
    9. Vascular and nerve interactions
    10. Coupling of bone formation and resorption
    11. Modeling and remodeling: the cellular machinery responsible for bone's material and structural strength during growth, aging, and drug therapy
    12. Aging and bone

    Section B Biochemistry
    13. Type I collagen structure, synthesis, and regulation
    14. Collagen cross-linking and bone pathobiology
    15. Secreted noncollagenous proteins of bone
    16. Bone proteinases
    17. Integrins and other cell surface attachment molecules of bone cells
    18. Intercellular junctions and cellecell communication in the skeletal system

    Section C Bone remodeling and mineral homeostasis
    19. Histomorphometric analysis of bone remodeling
    20. Phosphorus homeostasis and related disorders
    21. Magnesium homeostasis
    22. Metal ion toxicity in the skeleton: lead and aluminum
    23. Biology of the extracellular calcium-sensing receptor

    Section D Endocrine and paracrine regulation of bone
    24. Parathyroid hormone molecular biology
    25. Paracrine parathyroid hormonee related protein in bone: physiology and pharmacology
    26. Cardiovascular actions of parathyroid hormone/parathyroid hormoneerelated protein signaling
    27. Parathyroid hormone and parathyroid hormoneerelated protein actions on bone and kidney
    28. Receptors for parathyroid hormone and parathyroid hormoneerelated protein
    29. Structure and function of the vitamin D-binding proteins
    30. Vitamin D gene regulation
    31. Nonskeletal effects of vitamin D: current status and potential paths forward
    32. Cellular actions of parathyroid hormone on bone
    33. Calcitonin peptides
    34. Regulation of bone remodeling by central and peripheral nervous signals

    Section E Other systemic hormones that influence bone metabolism
    35. Estrogens and progestins
    36. Physiological actions of parathyroid hormone-related protein in epidermal, mammary, reproductive, and pancreatic tissues
    37. The pharmacology of selective estrogen receptor modulators: past and present
    38. Thyroid hormone and bone
    39. Basic and clinical aspects of glucocorticoid action in bone
    40. Diabetes and bone
    41. Androgen receptor expression and steroid action in bone

    Section F Local regulators
    42. Growth hormone, insulin-like growth factors, and IGF binding proteins

    Volume 2
    43. The periodontium
    44. Notch and its ligands
    45. Fibroblast growth factor (FGF) and FGF receptor families in bone
    46. Vascular endothelial growth factor and boneevascular interactions
    47. Transforming growth factor-b and skeletal homeostasis
    48. Bone morphogenetic proteins
    49. Extraskeletal effects of RANK ligand
    50. Local regulators of bone
    51. Prostaglandins and bone metabolism

    Part II: Molecular mechanisms of metabolic bone disease
    52. The molecular actions of parathyroid hormone/parathyroid hormoneerelated protein receptor type 1 and their implications
    53. Multiple endocrine neoplasia type 1
    54. Parathyroid hormone-related peptide and other mediators of skeletal manifestations of malignancy
    55. Localized osteolysis
    56. Genetic regulation of parathyroid gland development
    57. Genetic disorders caused by mutations in the parathyroid hormone/parathyroid hormonee related peptide receptor, its ligands, and downstream effector molecules
    58. Molecular basis of parathyroid h