Sample Size Calculations in Clinical Research
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- Hardcover
- Taschenbuch
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Form:Einzelkauf Download
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Sprache:Englisch
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eBook Format:ePUB 3
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- PDF 64,30 €
64,30 €
inkl. gesetzl. MwSt.Beschreibung
Produktdetails
Format
ePUB 3
Kopierschutz
Ja
Family Sharing
Nein
Text-to-Speech
Ja
Erscheinungsdatum
15.08.2017
Verlag
Taylor & Francis eBooksSeitenzahl
510 (Printausgabe)
Dateigröße
15599 KB
Auflage
3. Auflage
Sprache
Englisch
EAN
9781351727112
Praise for the Second Edition:
"... this is a useful, comprehensive compendium of almost every possible sample size formula. The strong organization and carefully defined formulae will aid any researcher designing a study." -Biometrics
"This impressive book contains formulae for computing sample size in a wide range of settings. One-sample studies and two-sample comparisons for quantitative, binary, and time-to-event outcomes are covered comprehensively, with separate sample size formulae for testing equality, non-inferiority, and equivalence. Many less familiar topics are also covered ..." - Journal of the Royal Statistical Society
Sample Size Calculations in Clinical Research, Third Edition presents statistical procedures for performing sample size calculations during various phases of clinical research and development. A comprehensive and unified presentation of statistical concepts and practical applications, this book includes a well-balanced summary of current and emerging clinical issues, regulatory requirements, and recently developed statistical methodologies for sample size calculation.
Features:
- Compares the relative merits and disadvantages of statistical methods for sample size calculations
- Explains how the formulae and procedures for sample size calculations can be used in a variety of clinical research and development stages
- Presents real-world examples from several therapeutic areas, including cardiovascular medicine, the central nervous system, anti-infective medicine, oncology, and women's health
- Provides sample size calculations for dose response studies, microarray studies, and Bayesian approaches
This new edition is updated throughout, includes many new sections, and five new chapters on emerging topics: two stage seamless adaptive designs, cluster randomized trial design, zero-inflated Poisson distribution, clinical trials with extremely low incidence rates, and clinical trial simulation.
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