• Produktbild: Nutrigenomics
  • Produktbild: Nutrigenomics

Nutrigenomics

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.06.2016

Abbildungen

XXI, 103 illus., 101 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Verlag

Springer

Seitenzahl

222

Maße (L/B/H)

24,1/16/1,9 cm

Gewicht

535 g

Auflage

1st ed. 2016

Sprache

Englisch

ISBN

978-3-319-30413-7

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

21.06.2016

Abbildungen

XXI, 103 illus., 101 illus. in color., farbige Illustrationen, schwarz-weiss Illustrationen

Verlag

Springer

Seitenzahl

222

Maße (L/B/H)

24,1/16/1,9 cm

Gewicht

535 g

Auflage

1st ed. 2016

Sprache

Englisch

ISBN

978-3-319-30413-7

Herstelleradresse

Springer-Verlag KG
Sachsenplatz 4-6
1201 Wien
AT

Email: GPSR Kontakt

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  • Produktbild: Nutrigenomics
  • Produktbild: Nutrigenomics
  • Section A: Introduction

    1. Nutrition and common diseases

    1.1 Human nutrition

    1.2 Nutrition and obesity

    1.3 Nutrition and cancer

    1.4 Nutrition and diabetes

    1.5 Nutrition and cardiovascular diseases

    1.6 Impact of exercise

    2. Human genomic variation

    2.1 Migration and evolutionary challenges of the modern human

    2.2 Diversity of human populations

    2.3 Genetic variants of the human genome

    2.4 The HapMap Project and haplotype blocks

    2.5 Genome-wide association studies

    2.6 Whole genome sequencing and the 1000 Genomes Project

    Section B: Molecular genetic basis

    3. Sensing nutrition

    3.1 Nutrient-sensing mechanisms

    3.2 Nutrient-sensing via nuclear receptors

    3.3 Functions and actions of PPARs

    3.4 Integration of lipid metabolism by LXRs and FXR

    3.5 Coordination of the immune response by VDR

    3.6 Circadian control of metabolic processes

    4. Nutrigenomics: Adapting the human genome to dietary changes and personalized nutrition

    4.1 Definition of nutrigenomics

    4.2 Vitamin D and skin color

    4.3 Human genetic adaption to dietary changes

    4.4 Regulatory SNPs and quantitative traits

    4.5 “Omics” analysis in nutrition sciences

    4.6 Integrative personal omics profile

    5. Nutritional epigenomics

    5.1 Epigenetic mechanisms

    5.2 Intermediary metabolism and epigenetic signaling

    5.3 One-carbon metabolism and DNA methylation

    5.4 Nutrition-triggered transgenerational epigenetics in mice

    5.5 Epigenetic programming in humans

    6. Nutritional signaling and aging

    6.1 Aging and conserved nutrient-sensing pathways

    6.2 Neuroendocrine aging regulation in humans and other mammals

    6.3 Caloric restriction from yeast to mammals

    6.4 Properties and functions of sirtuins

    6.5 Cellular energy status sensing by AMPK

    7. Chronic inflammation and metabolic stress

    7.1 Central role of monocytes and macrophages

    7.2 Acute and chronic inflammation

    7.3 Reverse cholesterol transport and inflammation

    7.4 M1 and M2 macrophages in adipose tissue

    7.5 ER stress response

    Section C: Links to diseases

    8. Obesity

    8.1 Definition of obesity

    8.2 Adipogenesis

    8.3 Energy homeostasis

    8.4 Hormonal regulation of food anticipation

    8.5 Adipose tissue as an endocrine organ

    8.6 Inflammation in adipose tissue

    8.7 Genetics of obesity

    9. Glucose homeostasis, insulin resistance and β cell failure

    9.1 Glucose homeostasis in health

    9.2 Principles of insulin signaling

    9.3 Central role of FOXO transcription factors

    9.4 Insulin resistance in skeletal muscle and liver

    9.5 β cell failure

    10. Diabetes

    10.1 Definition of diabetes

    10.2 Failure of glucose homeostasis in T2D and its treatment

    10.3 Genetics of T2D

    10.4 Thrifty gene hypothesis

    11. Hypertension, atherosclerosis and dyslipidemias

    11.1 Hypertension

    11.2 Mechanisms of atherosclerosis

    11.3 Cholesterol metabolism and lipoproteins

    11.4 Dyslipidemias

    12. Metabolic syndrome

    12.1 Definitions of the metabolic syndrome

    12.2 Whole body's perspective on the metabolic syndrome

    12.3 Metabolic syndrome in key metabolic organs

    12.4. Genetic and epigenetic basis of the metabolic syndrome