Part I Biochemistry, molecular biology and chemistry.- 1 H2S synthesizing enzymes: biochemistry and molecular aspects.- Part II Molecular mechanisms of action.- 2 Sulfhydration and H2S.- 3 Persulfide formation and H2S.- Part III Cardiovascular system.- 4 H2S and blood vessels - an overview.- 5 Hydrogen sulfide and urogenital tract.- 6 H2S - cardiac function and cardiac disease.- 7 H2S and platelets - a possible role in thrombosis?.- Part IV Inflammation and inflammatory disease.- 8 H2S and inflammation  - an overview.- 9 H2S and neuroinflammation.- Part V H2S and the nervous system.- 10 Brain, learning and memory: role in neurodegenerative diseases.- 11 H2S and pain - inflammatory and neuropathic.- Part VI H2S, angiogenesis and cancer.- 12 H2S and colon cancer.- 13 The role of H2S in cancer and tumor development.- Part VII H2S and ageing.- 14 H2S - a new approach to lifespan enhancement and healthy aging?.- Part VIII H2S, measurement and possible therapeutics?.- 15 Measurement of H2S - probes comes of age?.- 16 S-propargylcysteine - a novel H2S donor with therapeutic potential.- 17 Mitochondria-targetted sulfide donors.- 18 Medicinal chemistry - insights into the development of novel H2S donors.