Produktbild: Multivalency

Multivalency Concepts, Research and Applications

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

12.02.2018

Herausgeber

Jurriaan Huskens + weitere

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

25,1/17,6/2,7 cm

Gewicht

832 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-14346-8

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

12.02.2018

Herausgeber

Verlag

John Wiley & Sons Inc

Seitenzahl

416

Maße (L/B/H)

25,1/17,6/2,7 cm

Gewicht

832 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-1-119-14346-8

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Multivalency
  • List of Contributors xi
     
    Foreword xv
     
    Preface xvii
     
    Part I General Introduction to Multivalent Interactions 1
     
    1 Additivity of Energy Contributions in Multivalent Complexes 3
    Hans?-Jorg Schneider
     
    1.1 Introduction 3
     
    1.2 Additivity of Single Interactions - Examples 3
     
    1.3 Limitations of Additivity 7
     
    1.3.1 Free Energy Values DeltaG Instead of Enthalpic and Entropic Values DeltaH, TDeltaS 7
     
    1.3.2 Mismatch as Limitation of Additivity 9
     
    1.3.3 Medium Effects as Limiting Factor 12
     
    1.3.4 Strain and Induced Fit 12
     
    1.4 Cooperativity 13
     
    1.5 Allostery 14
     
    1.6 Conclusions 17
     
    References 18
     
    2 Models and Methods in Multivalent Systems 23
    Jurriaan Huskens
     
    2.1 Introduction 23
     
    2.1.1 General Introduction 23
     
    2.1.2 Multivalent versus Cooperative Interactions 24
     
    2.2 Numerical Data Analysis 25
     
    2.2.1 Model Simulations Using a Spreadsheet Approach 26
     
    2.2.2 Setting Up and Assessing Titrations 30
     
    2.2.3 Using Spreadsheet Simulations to Fit Experimental Data to a Model 36
     
    2.3 Models for Multivalent Systems 41
     
    2.3.1 The Simplest Multivalent System: A 1:1 Complex with Two Interaction Sites 41
     
    2.3.2 Multivalent Binding at Surfaces 46
     
    2.4 Special Multivalent Systems 53
     
    2.4.1 Increasing the Valency of Interfacial Assemblies: Dendrimers, Oligomers, and Polymers 53
     
    2.4.2 Heterotropic Interactions 58
     
    2.4.3 Kinetics and Dynamics 63
     
    2.5 Conclusions 68
     
    Acknowledgments 68
     
    References 68
     
    3 Design Principles for Super Selectivity using Multivalent Interactions 75
    Tine Curk, Jure Dobnikar, and Daan Frenkel
     
    3.1 Introduction 75
     
    3.1.1 Background: Ultra?-sensitive Response 75
     
    3.2 Super Selectivity: An Emergent Property of Multivalency 78
     
    3.3 Multivalent Polymer Adsorption 84
     
    3.4 Which Systems are Super Selective? 86
     
    3.4.1 Rigid Geometry Interactions 86
     
    3.4.2 Disordered Multivalency 87
     
    3.5 Design Principles for Super?-Selective Targeting 90
     
    3.6 Summary: It is interesting, but is it useful? 93
     
    Appendix 3.A: What Is Effective Molarity? 95
     
    Acknowledgements 98
     
    References 98
     
    4 Multivalency in Biosystems 103
    Jens Dernedde
     
    4.1 Introduction 103
     
    4.2 Cell-Cell Adhesion 104
     
    4.2.1 Homotypic Interactions, Cadherins Keep Cells Together 105
     
    4.2.2 Selectins, Heterotypic Cell Adhesion to Fight Infections 106
     
    4.2.3 Bacterial Adhesion by FimH 108
     
    4.3 Phase Transition, Multivalent Intracellular Assemblies 109
     
    4.4 Multivalency in the Fluid Phase, Pathogen Opsonization 111
     
    4.5 Conclusion 113
     
    Acknowledgment 113
     
    References 114
     
    Part II Multivalent Systems in Chemistry 121
     
    5 Multivalency in Cyclodextrin/Polymer Systems 123
    Akihito Hashidzume and Akira Harada
     
    5.1 Introduction 123
     
    5.2 General Perspectives of Multivalency in Cyclodextrin/Polymer Systems 125
     
    5.3 Typical Examples of Multivalency in Cyclodextrin/Polymer Systems 126
     
    5.3.1 Formation of Polymer Aggregates from Cyclodextrin?-Polymers and Guest?-Polymers 126
     
    5.3.2 Selectivity of Interaction Enhanced by Multivalency 127
     
    5.3.3 Self?-Healable Hydrogels Based on Multivalency 134
     
    5.4 Summary and Outlook 136
     
    Acknowledgments 136
     
    References 138
     
    6 Cucurbit[n-uril?-Mediated Multiple Interactions 143
    Zehuan Huang and Xi Zhang
     
    6.1 Introduction to Cucurbit