1. Acute Kidney Injury (AKI): Definitions and clinical context (Z. Ricci).- 2. Epidemiology of AKI (E. Hoste).- 3. Pathophysiology of AKI: Ischemia/reperfusion, Sepsis/inflammation, Toxicity, Vascular (A.B.J. Groeneveld,).- 4. Diagnostic work-up of the patient with suspected AKI: Oliguria, Metabolic acidosis (J. Prowle).- 5. Uremic toxins (R. Vanholder).- 6. The kidney and other organs/conditions: Heart, Cardiorenal syndromes, Uremic pericarditis, Lungs/Asthma renale, Liver/Hepatorenal syndrome, Gut/Uremic mucositis/GI permeability, Brain, Coagulation, Pregnancy (S. Bagshaw).- 7. Biomarkers for AKI (M. Ostermann).- 8. Prevention of AKI and protection of the kidney: Fluids, Vasopressors, Inotropes and vasodilators, Anti-inflammatory treatment, Antioxidants; Prevention of contrast associate nephropathy (M. Joannidis, co-authors ICM paper).- 9. Timing of renal replacement therapy (RRT) in AKI (S. Bagshaw,).- 10. Dosing of RRT (C.S.C. Bouman).- 11. Types of RRT: Continuous vs. intermittent, Convection vs. diffusion, Predilution vs. Postdilution, SLED, Replacement fluids, Membranes, Biocompatability (L.G. Forni).- 12. Anticoagulation for RRT: Heparin, Citrate, HIT (H.M. Oudemans).- 13. Metabolic aspects of continuous renal replacement therapy (CRRT): Control of acidosis, Control of electrolytes, Bioenergetic gain and loss, Loss of (micro)nutrient, Nutrition (O. Joannes Boyeau).- 14. CRRT: in sepsis, after cardiac surgery (P. Honore).- 15. CRRT in the pediatric population (Z. Ricci).- 16. Drug removal by CRRT and drug dosing in the patient on CRRT (M. Schetz).- 17. CRRT for intoxications (D. Cruz).- 18. How to avoid harm in the patient with AKI: summary of key points of previous chapters (H.M. Oudemans).- 19. Follow-up and long-term renal outcomes of patients surviving AKI (J. Prowle).