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Produktbild: Molecular and Biochemical Toxicology
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Molecular and Biochemical Toxicology

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.01.2018

Herausgeber

Robert C. Smart + weitere

Verlag

John Wiley & Sons

Seitenzahl

1040

Maße (L/B/H)

23,6/15,8/4,3 cm

Gewicht

1395 g

Auflage

5th edition

Sprache

Englisch

ISBN

978-1-119-04241-9

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.01.2018

Herausgeber

Verlag

John Wiley & Sons

Seitenzahl

1040

Maße (L/B/H)

23,6/15,8/4,3 cm

Gewicht

1395 g

Auflage

5th edition

Sprache

Englisch

ISBN

978-1-119-04241-9

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Molecular and Biochemical Toxicology
  • Preface xxix
     
    List of Contributors xxxi
     
    Section 1 Introduction 1
     
    1 Molecular and Biochemical Toxicology: Definition and Scope 3
    Ernest Hodgson and Robert C. Smart
     
    1.1 Introduction 3
     
    1.2 Sources of Information 5
     
    1.3 Toxicology 5
     
    1.4 Molecular and Cellular Toxicology 6
     
    1.5 Proteomics and Metabolomics 8
     
    1.6 Role of Molecular, Cellular, and Biochemical Toxicology: Implications for Risk Assessment 8
     
    1.7 Conclusions 9
     
    Suggested Reading 9
     
    Section 2 Techniques in Biochemical and Molecular Toxicology 11
     
    2 Molecular Techniques for the Study of Gene Function 13
    Yoshiaki Tsuji and Robert C. Smart
     
    2.1 Applicability of Molecular Techniques to Toxicology 13
     
    2.2 Overview of Genes, Chromatin, and Their Relationship 15
     
    2.3 Approaches to Characterize the Functions of Genes 20
     
    2.4 Gene Targeting Technologies 31
     
    2.5 Analysis of Gene Expression and Regulatory Mechanisms 35
     
    2.6 Methods to Evaluate Gene Function in an Animal Model 45
     
    References 54
     
    Suggested Reading 54
     
    3 Transcriptomics 55
    B. Alex Merrick
     
    3.1 Introduction 55
     
    3.2 Cellular Organization and the Transcriptome 58
     
    3.3 RNA Isolation 62
     
    3.4 Platforms for Transcriptome Analysis: Microarrays 64
     
    3.5 RNA?]seq: NextGen Sequencing of the Transcriptome 72
     
    3.6 Validation of Transcriptome Analysis 81
     
    3.7 Analysis of Gene Expression Data 82
     
    3.8 Summary 86
     
    References 87
     
    4 Proteomics 91
    Michael S. Bereman
     
    4.1 Introduction to Proteomics 91
     
    4.2 Mass Spectrometry 94
     
    4.3 Quantitation of Proteins by LC?]MS/MS 107
     
    4.4 Emerging Research Areas in Proteomics 109
     
    4.5 Summary 112
     
    Suggested
     
    Reading 112
     
    5 Metabolomics 115
    Susan C. J. Sumner, Wimal Pathmasiri, James E. Carlson, Susan L. McRitchie, and Timothy R. Fennell
     
    5.1 Introduction 115
     
    5.2 Endogenous and Exogenous Metabolites 116
     
    5.3 Study Design and Experimental Considerations 117
     
    5.4 Applications of Metabolomics 120
     
    5.5 Technologies for Targeted and Broad?]Spectrum Metabolomics 122
     
    5.6 Statistical and Multivariate Analysis and Pathway Mapping 127
     
    5.7 Summary 130
     
    Acknowledgment 130
     
    References 131
     
    6 Cellular Techniques 135
    Sharon A. Meyer and Barbara A. Wetmore
     
    6.1 Introduction 135
     
    6.2 Cellular Studies in Intact Tissue 137
     
    6.3 Studies
     
    6.4 Monolayer Cell Culture 142
     
    6.5 Observation of Cultured Cells 148
     
    6.6 Indicators of Toxicity 149
     
    6.7 Important Considerations and Advances 152
     
    6.8 Replacement of Animal Testing with Cell Culture Models 155
     
    6.9 Conclusion 157
     
    Suggested Reading 157
     
    Journals 158
     
    7 Basic Concepts of Molecular Epidemiological Research Methods 159
    Cathrine Hoyo, David A. Skaar, and Randy L. Jirtle
     
    7.1 Introduction 159
     
    7.2 Molecular Epidemiology 160
     
    7.3 Descriptive Epidemiologic Study Designs 164
     
    7.4 Analytic Epidemiologic Studies 167
     
    7.5 Experimental Studies 173
     
    7.6 Inferring Causality from Molecular Epidemiologic Data 174
     
    7.7 Summary 182
     
    References 183
     
    Suggested Reading 184
     
    Reading Materials Related to Examples 184
     
    Section 3 Mechanisms in Molecular and Biochemical Toxicology 187
     
    8 Phase I and Phase II Metabolism and Metabolic Interactions: A Summary 189
    Ernest Hodgson
     
    8.1