Years with Elizabeth and James Miller: In Appreciation.- I. Chemistry and Biology of Biological Reactive Intermediates.- Reactivity and Tumorigenicity of Bay-Region Diol Epoxides Derived From Polycyclic Aromatic Hydrocarbons.- Chemistry of Covalent Binding: Studies with Bromobenzene and Thiobenzamide.- Role of Thiols in Protection Against Biological Reactive Intermediates.- Role of Parenchymal Versus Non-Parenchymal Cells in the Control of Biologically Reactive Intermediates.- Significance of Covalent Binding of Chemically Reactive Metabolites of Foreign Compounds to Proteins and Lipids.- II. Biology of Cytochrome P-450 and Related Aspects of the Mixed Function Oxidase.- Structure and Function of Cytochrome P-450.- Antibodies As Probes of Cytochrome P450 Isozymes.- Age and Sex Differences in Constitutive Forms of Cytochrome P-450 of Rat Liver Microsomes.- Identification of Intratissue Sites for Xenobiotic Activation and Detoxication.- Monoclonal Antibody-Directed Analysis of Cytochrome P-450.- III. Suicide Substrates of Cytochrome P-450.- Drug Interactions with Macrolide Antibodies: Specificity of Pseudo-Suicide of Inhibition and Induction of Cytochrome P-450.- Isomeric Composition of N-Alkylated Protoporplhyrins Produced by Substituted Dihydropyridines In Vivo and In Vitro.- IV. Characterization and Toxicological Significance of Phase II Enzymes.- UDP-Glucuronyltransferases and Their Toxicological Significance.- Expression and Sequence Analysis of Rat Liver Glutathione S-Transferase Genes.- Rat Cytosolic Epoxide Hydrolase.- Short Communications.- Multiplicity of Cytochrome P-450 in Morris Hepatoma.- The Metabolism of Benzene and Phenol by a Reconstituted Purified Phenobarbital-Induced Rat Liver Mixed Function Oxidase System.- Comparison of The Metabolism of Benzene and its Metabolite Phenol in Rat Liver Microsomes.- Further Evidence for a Role of Isozymes of P450 in the Metabolism and Toxicity of Carbon Disulfide (CS2).- Effect of a Suicide Substrate on the Metabolism of Steroids and Xenobiotics and on Cytochrome P-450 Apoproteins.- Activation of Cytochrome P-450 Heme In Vivo.- The FAD-Containing Monooxygenase of Lung and Liver Tissue From Rabbit, Mouse and Pig: Species and Tissue Differences.- Oxygen Radical Formation During Redox Cycling of Bleomycin-Fe(III) Catalyzed by NADPH-Cytochrome P-450 Reductase of Liver Microsomes and Nuclei.- Superoxide Dismutase Modification and Genotoxicity of Transition-Metal Ion Chelators.- Toxicologic Implications of the Iron-Dependent Activation of Bleomycin A2 By Mouse Lung Microsomes.- The Peroxidative Activation of Butylated Hydroxytoluene to BHT-Quinone Methide and Stilbenequinone.- Activation of Xenobiotics by Human Polymorphonuclear Leukocytes via Reactive Oxygen-Dependent Reactions.- Metabolism of Diehtylstilbestrol by Horseradish Peroxidase and Prostaglandin Suynthase-Evidence For A Free Radical Intermediate.- Thiyl Radicals--Their Generation and Further Reactions.- Mechanism of the Cytochrome P-450 Catalyzed Isomerization of Hydroperoxides.- Indole-3-Carbinol Inhibits Lipid Peroxidation in Cell-Free Systems.- Glutathione Peroxidase and Reactive Oxygen Species in TCDD-Induced Lipid Peroxidation.- Activation of Nitrosamines to Mutagens by Rat and Rabbit Nasal, Lung and Liver S-9 Homogenates.- Structure of the Adduct of Glutathione and Activated 3-Mathylindole.- Studies on the Mechanisms of S-Cysteine Conjugate Metabolism and Toxicity in Rat Liver, Kidney and Cell Culture Model.- Formation of Identification of Naphthoquinone Glutathione Conjugates Following Microsomal Metabolism of 1-Naphthol.- The Formation of N-Glucuronides Catalyzed by Purified Hepatic 17 ? -Hydroxysteroid and 3? -Hydroxysteroid UDP-Glucuronyltransferase.- Improved Method For Determination of Cellular Thiols, Disulfides and Protein Mixed Disulfides using HPLC with Electrochemical Detection.- Arylsulfotransferase IV Catalyzed Sulfation of 1-Naphthalenemethanol.- Activated Phase II Metabolites: Comparison of Alkylation by 1-0-Acyl Glucuronides and Acyl Sulfates.- Reactions of Oxaprozin-1-0-Acyl Glucuronide in Solutions of Human Plasma and Albumin.- V. Role of Sulfur in Metabolic Activation and Detoxication.- Nephrotoxic Amino Acid and Glutathione S-Conjugates: Formation and Renal Activation.- The Role of Glutathione in the Toxicity of Xenobiotic Compounds: Metabolic Activation of 1,2-Dibromoethane By Glutathione.- A Comparison of the Alkylating Capabilities of the Cysteinyl and Glutationyl Conjugates of 1,2-Dichloroethane.- Covalent Reactions in the Toxicity of SO2 and Sulfite.- VI. Active Oxygen and Triol Oxidations.- One- And Two-Electron Oxidation of Reduced Glutathione By Peroxidases.- Reactive Oxygen Species Formed In Vitro and in Cells: Role of Thiols (GSH) Model Studies with Xanthine Oxidase and Horseradish Peroxidase.- Active Oxygen and Toxicity.- VII. Reactive Metabolites of Nitrogenous Compounds.- Studies on the Mechanism of Activation and the Mutagenicity of Ronidazole, a 5-Nitroimidazole.- Carcinogen-DNA Adduct Formation as a Predictor of Metabolic Activation Pathways and Reactive Intermediates in Benzidine Carcinogenesis.- Purification, Properties and Function of N-Hydroxyarylamine 0-Acetyltransferase.- Metabolism and Carcinogenicity of Nitrotoluenes.- Hydroxylamines and Hemolytic Anemia.- Special Presentation.- Electrophilic Sulfuric Acid Ester Metabolites as Ultimate Carcinogens.- VIII. Toxicity of Biological Reactive Intermediates.- Biological Reactive Intermediates of Mycotoxins.- Biological Reactive Intermediates of Pyrrolizidine Alkaloids.- Mutagens and Carcinogens Formed During Cooking.- Quinone Imines as Biological Reactive Intermediates.- IX. Biological Reactive Intermediates and the Immune System.- The Role of Reactive Intermediates in Sulfhydryl-Dependent Immunotoxicity: Interference with Microtubule Assembly and MicrotubuleDependent Cell Function.- Investigation of the Immunological Basis of Halothane-Induced Hepatotoxicity.- Inhibition of RNA Synthesis in Mouse Macrophages and Lymphocytes by Benzene and its Metabolites.- Short Communications.- p-Nitrosophenetole: A Reactive Intermediate of Phenacetin that Binds To Protein.- Mechanism of Fasting-Induced Suppression of Acetaminophen Glucuronidation in The Rat.- Effect of Diethyl Ether on the Bioactivation, Detoxification and Hepatotoxicity of Acetaminophen in vitro and in vivo.- Piperonyl Butoxide Reduces Salicylate-Induced Nephrotoxicity and Covalent Binding in Male Rats.- Cross-Linking of Protein Molecules by the Reactive Metabolite of Acetaminophen, N-Acetyl-p-Benzoquinone Imine, and Related Quinoid Compounds.- Acetaminophen as a Cosubstrate and Inhibitor of Prostaglandin H Synthetase.- The Fate of 4-Cyanoacetanilide in Rats and Mice: The Mechanism Of Formation Of A Novel Electrophilic Metabolite.- Mechanistic Studies of Acetamide Hepatocarcinogenicity.- Reactions of Glutathione with Oxidative Intermediates of Acetaminophen.- Flavin-Containing Monooxygenase Activity in Human Liver Microsomes.- S9-Dependent Activation of 1-Nitropyrene and 3-Nitrofluoranthene in Bacterial Mutagenicity Assays.- Formation of a Ring-Opened Product from Benzene in a Hydroxyl Radical Generating System.- H-2 Modulation of Lauryl Hydrocarbon Hydroxylase Induction and the Mutagenicity of Benzo(a)Pyrene after 3-Methylcholanthrene Treatment.- Stereoselectivity of Rat Liver Cytochrome P-450 Isozymes: Direct Determination of Enantiomeric Composition of K-Region Epoxides Formed in the Metabolism of Benz(a)anthracene and 7,12-Dimethylbenz(a)anthracene.- Induction of Unscheduled DNA Synthesis in Human Mononuclear Leukocytes by Oxidative Stress.- Deoxyguanosine Adducts Formed from Benzoquinone and Hydroquinone.- 3-Hydroxy-Trans-7,8-Dihydro-7,8-Dihydroxy-Benzo(a)Pyrene, a Metabolite of 3-Hydroxybenzo(a)pyrene.- Time Course of The Effect of 4-Hydroperoxycyclophosphamide On Limb Differentiation in vitro.- Hepatic Pathological Changes due to Hydroxyalkenals.- Clofibrate Selectively Induces Azoreduction of Dimethylaminoazobenzene (DAB) by Rat Liver Microsomes.- Intracellular Dissipative Structures (IDS) as Ultimate Targets of Chemical Cytotoxicity.- Helenalin: Mechanism of Toxic Action.- Evidence for Stereoselective Production of Phenytoin (5,5-Diphenylhydantoin) Arene Oxides In Man.- Tissue Distribution and Covalent Binding of [14C]1,1-Dichloroethylene in Mice: in vivo and in vitro Studies.- Inhibition of Respiration in Rabbit Proximal Tubules by Bromophenols and 2-Bromohydroquinone.- In vitro Covalent Binding of 14C-Mibolerone to Rat Liver Microsomes.- Chemistry of Metabolites of Thioureas.- Conversion of Phenytoin to Reactive Metabolites in Rat Liver Microsomes.- Comparison of N-Methylformamide-Induced Hepatotoxicity and Metabolism in Rats and Mice.- Epoxidation of 1,3-Butadiene in Liver and Lung Tissue of Mouse, Rat, Monkey and Man.- Enzyme Catalysed Cleavage of the N-N Bond of N-Nitrosamines.- Use of the Chemiluminigenic Probes Luminol and Lucigenin for the Detection of Active Oxygen Species in Hepatic Microsomes and in Intact Hepatocytes.- X. Implications of Renobiotic Metabolism for Human Disease.- Altered Expression of Oncogenes in Mouse Epidermis Following Exposure To Benzo(A)Pyrene Diol Epoxides.- Acetaminophen Toxicity in Isolated Hepatocytes.- Mechanism of Organ Specificity in Nitrosamine Carcinogenesis.- Biological Reactive Metabolites in Human Toxicity.- Metabolic Host Factors as Modifiers of Reactive Intermediates Possibly Involved in Human Cancer.- Closing Remarks.
