Organic Stereochemistry Guiding Principles and Biomedicinal Relevance
-
- Englisch ausgewählt
85,99 €
inkl. gesetzl. MwSt.,
Beschreibung
Produktdetails
Einband
Taschenbuch
Erscheinungsdatum
23.04.2014
Herausgeber
Bernard Testa + weitereVerlag
Helvetica Chimica ActaSeitenzahl
400
Maße (L/B/H)
2/21/23 cm
Gewicht
1084 g
Auflage
1. Auflage
Sprache
Englisch
ISBN
978-3-906390-69-7
This textbook presents the molecular scale of matter in the broad diversity and richness of its three dimensions, giving due attention when relevant to the temporal dimension in which molecules exist, act, and react.
The focus is on two significant fields of three-dimensional chemistry: a presentation of the guiding principles in organic stereochemistry, followed by a focus on the biochemical and medicinal relevance of this discipline.
The treatment of Guiding Principles gives priority to didactic clarity and nomenclature issues, as detailed and illustrated in Parts 1 to 4:
'Symmetry Elements and Operations, Classification of Stereoisomers'
'Stereoisomerism Resulting from One or Several Stereogenic Centers'
'Other Stereogenic Elements: Axes of Chirality, Planes of Chirality, Helicity, and (E,Z)-Diastereoisomerism'
'Isomerisms about Single Bonds and in Cyclic Systems'
This is followed by Parts 5 to 8 which focus on the biomedicinal relevance of stereochemistry, with special reference to the biochemistry and pharmacology of medicinal compounds.
Here, examples and applications are discussed and illustrated based on their relevance to a given specific stereochemical aspect:
'Chirality in Molecular and Clinical Pharmacology'
'The Conformational Factor in Molecular Pharmacology'
'The Concept of Substrate Stereoselectivity in Biochemistry and Xenobiotic Metabolism'
'Prostereoisomerism and the Concept of Product Stereoselectivity in Xenobiotic Metabolism'
Finally, the book contains a gift for broad-minded readers with an interest in the historical roots of stereochemistry:
'Molecular Chirality in Chemistry and Biology: Historical Milestones'
Key features:
* Consists entirely of beautifully produced colored figures
* Includes marginal notes, giving clear-cut short definitions of terms used in the corresponding caption
* Provides an alphabetic glossary of terms
* Offers an extensive index
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