Preface xix
Tribute xxi
List of Contributors xxviii
About the Companion Website xxxiii
CHAPTER 1 Systematic Reviews in Health Research: An Introduction 1
Matthias Egger, Julian P.T. Higgins, and George Davey Smith
PART I Principles and Procedures 17
CHAPTER 2 Principles of Systematic Reviewing 19
Julian P.T. Higgins, George Davey Smith, Douglas G. Altman, and Matthias Egger
CHAPTER 3 Identifying Randomized Controlled Trials 36
Julie Glanville and Carol Lefebvre
CHAPTER 4 Assessing the Risk of Bias in Randomized Trials 55
Matthew J. Page, Douglas G. Altman, and Matthias Egger
CHAPTER 5 Investigating and Dealing with Publication Bias and Other Reporting Biases 74
Matthew J. Page, Jonathan A.C. Sterne, Julian P.T. Higgins, and Matthias Egger
CHAPTER 6 Managing People and Data 91
Eliane Rohner, Julia Bohlius, Bruno R. da Costa, and Sven Trelle
CHAPTER 7 Reporting and Appraisal of Systematic Reviews 109
Larissa Shamseer, Beverley Shea, Brian Hutton, and David Moher
PART II Meta-Analysis 129
CHAPTER 8 Effect Measures 131
Julian P.T. Higgins, Jonathan J. Deeks, and Douglas G. Altman
CHAPTER 9 Combining Results Using Meta-Analysis 159
Jonathan J. Deeks, Richard D. Riley, and Julian P.T. Higgins
CHAPTER 10 Exploring Heterogeneity 185
Julian P.T. Higgins and Tianjing Li
CHAPTER 11 Dealing with Missing Outcome Data in Meta-Analysis 204
Ian R. White and Dimitris Mavridis
CHAPTER 12 Individual Participant Data Meta-Analysis 220
Mark C. Simmonds and Lesley A. Stewart
CHAPTER 13 Network Meta-Analysis 238
Georgia Salanti and Julian P.T. Higgins
CHAPTER 14 Dose-Response Meta-Analysis 258
Nicola Orsini, Susanna C. Larsson, and Georgia Salanti
PART III Specific Study Designs 271
CHAPTER 15 Systematic Reviews of Nonrandomized Studies of Interventions 273
Jelena Savovic, Penny F. Whiting, and Olaf M. Dekkers
CHAPTER 16 Systematic Reviews of Diagnostic Accuracy 296
Yemisi Takwoingi and Jonathan J. Deeks
CHAPTER 17 Systematic Reviews of Prognostic Factor Studies 324
Richard D. Riley, Karel G.M. Moons, Douglas G. Altman, Gary S. Collins, and Thomas P.A. Debray
CHAPTER 18 Systematic Reviews of Prediction Models 347
Gary S. Collins, Karel G.M. Moons, Thomas P.A. Debray, Douglas G. Altman, and Richard D. Riley
CHAPTER 19 Systematic Reviews of Epidemiological Studies of Etiology and Prevalence 377
Matthias Egger, Diana Buitrago-Garcia, and George Davey Smith
CHAPTER 20 Meta-Analysis in Genetic Association Studies 396
Gibran Hemani
PART IV Cochrane and Guideline Development 413
CHAPTER 21 Cochrane: Trusted Evidence. Informed Decisions. Better Health 415
Gerd Antes, David Tovey, and Nancy Owens
CHAPTER 22 Using Systematic Reviews in Guideline Development: The GRADE Approach 424
Holger J. Schünemann
PART V Outlook 449
CHAPTER 23 Innovations in Systematic Review Production 451
Julian Elliott and Tari Turner
CHAPTER 24 Future for Systematic Reviews and Meta-Analysis 463
Shah Ebrahim and Mark D. Huffman
PART VI Software 481
CHAPTER 25 Meta-Analysis in Stata 483
David J. Fisher, Marcel Zwahlen, Matthias Egger, and Julian P.T. Higgins
CHAPTER 26 Meta-Analysis in R 510
Guido Schwarzer
CHAPTER 27 Comprehensive Meta-Analysis Software 535
Michael Borenstein
Index 549
