• Table of Contents


• 1. History and Nomenclature


• Pick's Disease: The Contributions of Arnold Pick


• Maintaining Early Traditions and Refining Diagnosis: Delay, Brion, Escourolle, Malamud and Constantinidis


• Splintering of Pick's Disease into Multiple Subtypes


• The Biological Revolution


• FTD Now: Where Are We?


• The Future


• References


• 2. The Clinical Syndrome of bvFTD


• Overview


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• BVFTD: Current State And Research Advances


• References


• 3.The Clinical Syndrome of NFVPPA


• Overview


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• NFVPPA: Current State And Research Advances


• References


• Related Disorders: FTD-ALS


• Overview


• Amyotrophic Lateral Sclerosis


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• FTD-ALS: Current State and Research Advances


• References


• 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy


• Overview


• Creativity


• Treatment


• svPPA: Current State and Research Advances


• Semantic Knowledge and the Anterior Temporal Lobes


• Autoimmunity, Left-Handedness, Head Trauma and svPPA


• Summary


• References


• 4. Progressive Nonfluent/Agrammatic Aphasia


• Overview


• Case History


• Comment


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• nfvPPA: Current State and Research Advances


• Diagnosis from Clinical Syndrome to Molecular Diagnosis


• Neurolinguistic and Neuroplasticity Discoveries


• References


• 5. Related Disorders: FTD-ALS


• Overview


• Amyotrophic Lateral Sclerosis


• Case History


• Comment


• Clinical Features and Anatomy


• El Escorial Criteria


• Genetic and Pathological Correlates


• Neuropathology


• Differential Diagnosis


• Treatment


• FTD-ALS: Current State and Research Advances


• Clinical-Pathological Considerations


• Molecular Considerations


• References


• 6. Related Disorders: Corticobasal Degeneration and Progressive Supranuclear Palsy


• Overview


• Corticobasal Degeneration (CBD)


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• Progressive Supranuclear Palsy (PSP)


• Clinical Features and Anatomy


• Genetic and Pathological Correlates


• Differential Diagnosis


• Treatment


• CBD and PSP: Current State and Research Advances


• References


• 7. A Primer of FTLD Neuropathology


• General Features


• Overview of Tau-Related Neuropathology in FTLD


• Overview of TDP-43 and FUS Related Neuropathology in FTLD


• Gross Anatomical and Microscopic Changes in FTLD


• Special Features of FTLD Pathology


• FTLD Neuropatholoy: Current State and Research Advances


• 8. FTD Genes


• Overview


• Genes Implicated in FTD


• Genes That Modify FTD Expression


• Management and Genetic Counseling


• References


• 9. FTD Reflections Upon Psychology and Philosophy


• Emotions


• The Self


• Free Will


• Religious Beliefs


• Psychology


• von Economo Neurons


• References


• 10. Treatments


• Diagnosis


• bvFTD: Targeting Symptoms, Educating the Family


• svPPA: Targeting Symptoms, Educating the Family


• nfvPPA: Targeting Symptoms and Educating the Family


• Late Stages of FTD


• Early Interventions


• Pharmacological Review


• Non-Pharmacological Therapies


• Complementary and Alternative Medicine


• Language Impairment


• Future Treatments


• Conclusions


• References