Produktbild: NMR in Pharmaceutical Sciences

NMR in Pharmaceutical Sciences

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.09.2015

Herausgeber

Everett Jeremy R. + weitere

Verlag

Wiley

Seitenzahl

512

Maße (L/B/H)

25,1/19,2/2,7 cm

Gewicht

1247 g

Sprache

Englisch

ISBN

978-1-118-66025-6

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

04.09.2015

Herausgeber

Verlag

Wiley

Seitenzahl

512

Maße (L/B/H)

25,1/19,2/2,7 cm

Gewicht

1247 g

Sprache

Englisch

ISBN

978-1-118-66025-6

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: NMR in Pharmaceutical Sciences
  • Contributors xi

    Series Preface xvii

    Preface xix

    Part A: Introduction 1

    1 Drug Discovery and Development: The Role of NMR
    Jeremy R. Everett 3

    Part B: NMR Theory & Experimental Methods 21

    2 Modern NMR Pulse Sequences in Pharmaceutical R&D
    John A. Parkinson 23

    3 Experimental NMR Methods for Pharmaceutical Research and Development
    Anthony C. Dona 41

    4 19F NMR Spectroscopy: Applications in Pharmaceutical Studies
    John C. Lindon and Ian D. Wilson 53

    5 Quantitative NMR Spectroscopy in Pharmaceutical R&D
    Ulrike Holzgrabe 63

    6 High-throughput NMR in Pharmaceutical R&D
    John C. Hollerton 79

    7 Multivariate Data Analysis Methods for NMR-based Metabolic Phenotyping in Pharmaceutical and Clinical Research
    Kirill A. Veselkov, James S. McKenzie, and Jeremy K. Nicholson 89

    Part C: Idea to Lead 103

    8 The Role of NMR in Target Identification and Validation for Pharmaceutical R&D
    Krishna Saxena and Harald Schwalbe 105

    9 High-resolution MAS NMR of Tissues and Cells
    Leo L. Cheng 117

    10 NMR Studies of Inborn Errors of Metabolism
    Sarantos Kostidis and Emmanuel Mikros 131

    11 NMR-based Structure Confirmation of Hits and Leads in Pharmaceutical R&D
    Philip J. Sidebottom 147

    12 Fragment-based Drug Design Using NMR Methods
    Leonor Puchades-Carrasco and Antonio Pineda-Lucena 155

    13 Hit Discovery from Natural Products in Pharmaceutical R&D
    Olivia Corcoran 173

    Part D: Lead to Drug Candidate 183

    14 NMR-based Structure Determination of Drug Leads and Candidates
    Torren M. Peakman 185

    15 Mixture Analysis in Pharmaceutical R&D Using Hyphenated NMR Techniques
    Ian D. Wilson and John C. Lindon 197

    16 Conformation and Stereochemical Analysis of Drug Molecules
    Gary J. Sharman 207

    17 NMR Methods for the Assignment of Absolute Stereochemistry of Bioactive Compounds
    Jose M. Seco and Ricardo Riguera 221

    18 Applications of Preclinical MRI/MRS in the Evaluation of Drug Efficacy and Safety
    Thomas M. Bocan, Lauren Keith, and David M. Thomasson 255

    19 Practical Applications of NMR Spectroscopy in Preclinical Drug Metabolism Studies
    Raman Sharma and Gregory S. Walker 267

    20 Preclinical Drug Efficacy and Safety Using NMR Spectroscopy
    Muireann Coen and Ian D. Wilson 281

    21 Characterization of Pharmaceutical Compounds by Solid-state NMR
    Frederick G. Vogt 297

    22 Structure-based Drug Design Using NMR
    Mark Jeeves, Lee Quill, and Michael Overduin 317

    23 Pharmaceutical Technology Studied by MRI
    David G. Reid and Stephen J. Byard 331

    Part E: Clinical Development 345

    24 NMR-based Metabolic Phenotyping for Disease Diagnosis and Stratification
    Beatriz Jiménez 347

    25 NMR-based Pharmacometabonomics: A New Approach to Personalized Medicine
    Jeremy R. Everett 359

    26 Clinical MRI Studies of Drug Efficacy and Safety
    David G. Reid, Paul D. Hockings, and Nadeem Saeed 373

    27 The Role of NMR in the Protection of Intellectual Property in Pharmaceutical R&D
    Frederick G. Vogt 385

    Part F: Drug Manufacture 395

    28 Analysis of Counterfeit Medicines and Adulterated Dietary Supplements by NMR
    Myriam Malet-Martino and Robert Martino 397

    29 Pharmaceutical Industry: Regulatory Control and Impact on NMR Spectroscopy
    Andrea Ruggiero and Sarah K. Branch 413

    30 NMR Spectroscopy in the European and US Pharmacopeias
    Helen Corns and Sarah K. Branch 425

    31 NMR in Pharmaceutical Manufacturing
    Edwin Kellenbach and Paulo Dani 441

    Index 453