Aims and mission of  regulatory toxicology.- Working areas of regulatory toxicology.- National and international collaboration in regulatory toxicology.- The regulatory process in toxicology.- Quality assurance in regulatory toxicology.- Toxicological risk assessment.- Characterization of physicochemical parameters in toxicology.- Examination of acute and chronic toxicity.- Examination of organ-toxicity.- Specific toxicity tests for neurotoxicity , immunotoxicity, allergy, irritation, reprotoxicity and carcinogenicity.- Toxicity testing in vitro. Regulatory aspects.- New and future toxicological assays and their regulation.- Computer-based prediction models in regulatory toxicology.- Metabolism tests  in regulatory toxicology.- Toxicokinetic tests.- Toxicodynamic tests.- Omics in  toxicology.- International regulation of toxicological test systems.- Epidemiological methods in regulatory toxicology.- Studies in volunteers and its regulation.- Statistical evaluation methods in toxicology.- Dose-Response analysis, Identification of threshold levels for chemicals.- Extrapolation-procedures for carcinogenic and non-carcinogenic compounds.- Probabilistic methods in  toxicology.- Toxicodynamic models.- Toxicokinetic models.- Exposure analysis for indoor contaminants.- Exposure scenarios in  toxicology.- Quality criteria for primary literature in  toxicology.- Data-mining  in  toxicology.- Principles of analytical chemistry for  toxicology.- Principles of analytical chemistry for  toxicology.- Benchmark dose in regulatory toxicology.- Uncertainty analysis in exposure assessment. Relevance for regulatory toxicology.- Do carcinogens have a threshold dose? pro and contra.- Single compounds vs combination effects in toxicology.- Biomolecules vs smaller chemicals in toxicology.- Sensitive humans vs average persons in toxicology.- Extrapolation factors and safety factors in toxicology.- Background exposure vs additional exposure in human biomonitoring.- Adverse effects vs non-adverse effects in toxicology.- Health based threshold ADI vs MOS in  toxicology.- Precaution principle vs danger prevention in toxicology.- Hygenic vs toxicological approaches in regulation.- Protected property and  protection level in regulatory toxicology.- Ethical issues in Science. Focus on regulatory toxicology.- Current  role of the risk concept in regulatory toxicology.- Risk cycles in  toxicology.- Risk minimization in drug development.  Regulatory aspects.- Importance of physical-chemical properties for toxicological risk assessment.- Importance of intrinsic toxic properties for risk assessment.- Importance of metabolism. Mechanistic considerations relevant for toxicological regulation.- Dose Response Relationship and Extrapolation in Toxicology. Mechanistic and statistical considerations.- Importance of exposure level for risk toxicological assessment.- Risk characterization in regulatory toxicology.- Risk evaluation regulatory toxicology.- Risk comparision in toxicology.- Risk-benefit considerations in toxicology.- Toxicological risk assessment in different jurisdictions.- Purpose of risk management in regulatory toxicology.- Assessment of limit values in regulatory toxicology.- Limit value setting in different  areas of regulatory toxicology.- Registration and approval in regulatory toxicology.- Classification and labelling regulatory toxicology.- Human Biomonitoring. Its importance in toxicological regulation.- Restrictions and prohibitions as tools in regulatory toxicology.- Observance of susceptible population groups in regulatory toxicology.- Toxicological  report.- Risk managment in toxicological disasters.- Institutionalized participation in regulatory toxicology.- Risk communication.- Dealing with diseases that have been attributed to chemical exposures.- Reach (and CLP). Its role in regulatory toxicology.- Bridging. The regulation of toxic mixtures.- Regulatory aspects of food toxicology.- Notification of Cosmetic Products and dangerous mixtures in regulatory toxicology.- Checklist: Toxicological risk assessment in practice.- Glossary of  toxicology and risk terms.- Limit values and guideline values in regulatory toxicology.-