Preface: Knowledge and Innovation Challenge Stavros A. Zenios Introduction: Cities, Regions and Universities as Knowledge and Innovation Creators Roberta Capello, Agnieszka Olechnicka and Grzegorz Gorzelak Part I: Universities: Local/Regional Institutions Of Knowledge Creation And Innovation In National And International Contexts 1. Science-based Activities in European Regions: The Knowledge-Innovation Nexus Roberta Capello 2. The Civic University: Connecting the Global and the Local John Goddard, Paul Vallance and Louise Kempton 3. The Innovation Process of European Regions: From Absorption to Knowledge Creation Capacities of European Regions Malgorzata Runiewicz-Wardyn 4. Universities as Knowledge Nodes in Open Innovation Systems Suntje Schmidt 5. Regional Cooperation or External Links? Spatial Proximity in Science-Business Relations in Poland Agnieszka Olechnicka 6. ‘What do You Offer?’: Interlinkages of Universities and High-Technology Companies in Science and Technology Parks in Berlin and Seville Sascha Brinkhoff, Lech Suwala and Elmar Kulke 7. Relations Between International Research Collaboration, Scientific Production and the Impact of Research at Polish Universities Krzysztof Klincewicz Part II: Universities, Entrepreneurship and Innovation-driven Development 8. The Research University, Entrepreneurship and Regional Development: Research Propositions and Current Evidence Helen Lawton Smith and Sharmistha Bagchi-Sen 9. The Second Coming of the Triple Helix and the Emergence of Hybrid Innovation Environments Martin Meyer, Kevin Grant and Jari Kuusisto 10. Bringing University Knowledge to Market: Experience in The Netherlands Marina Van Geenhuizen 11. Academic Entrepreneurs in Post-Socialist Central European Countries: Evidence from the Hungarian Biotechnology Sector Katalin Erdõs and Attila Varga 12. Universities, Researchers and Their Perspective on the Fulfilment of the Third Role: The Case of Czechia Pavla Žížalová, Vladislav Čadil 13. ‘Entrepreneurial Universities, Entrepreneurial Students’. Higher Education and Creation of Innovation in the Spanish Area Ana Lanero, José Luis Vázquez and María Purificación García 14. The Role of University Medical Centres in an Innovation Network Dennis Häckl, Hans Wiesmeth, Oliver Fiala Part III: Academic Footsteps In The City 15. The ‘Adaptive University’: Responding to New Expectations and Coping with Established Tasks Jan Sadlak 16. Absorption of Human Capital by Academic Cities in Poland Mikołaj Herbst 17. The Innovative Potential of Kyiv: Overestimated and Underused Olga Mrinska 18. University and Regional Development in the Northern European Peripheries: The Case of the University of Tromsø Kazimierz Musiał