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Band 8

Receptors and Other Targets for Toxic Substances Proceedings of the European Society of Toxicology, Meeting Held in Budapest, June 11–14, 1984

Aus der Reihe Archives of Toxicology

99,99 €

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Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.12.1985

Herausgeber

P.L. Chambers + weitere

Verlag

Springer Berlin

Seitenzahl

520

Maße (L/B/H)

24,4/17/2,9 cm

Gewicht

960 g

Auflage

1985

Sprache

Englisch

ISBN

978-3-540-13670-5

Beschreibung

Produktdetails

Einband

Taschenbuch

Erscheinungsdatum

01.12.1985

Herausgeber

Verlag

Springer Berlin

Seitenzahl

520

Maße (L/B/H)

24,4/17/2,9 cm

Gewicht

960 g

Auflage

1985

Sprache

Englisch

ISBN

978-3-540-13670-5

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: GPSR Kontakt

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  • Produktbild: Receptors and Other Targets for Toxic Substances
  • Produktbild: Receptors and Other Targets for Toxic Substances
  • On the Occasion of the 25th Meeting of the European Society of Toxicology.- Young Scientists Award Lecture 1984: Species Differences in Carcinogenicity and Peroxisome Proliferation due to Trichloroethylene: A Biochemical Human Hazard Assessment.- The Role of the Receptor in Toxicology.- The Role of Immunoreceptors.- The Role of the Estrogen Receptor in Diethylstilbestrol Toxicity.- The Role of Receptors in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD Toxicity).- The Oncogene and its Potential Role in Carcinogenesis.- Brain Glucocorticoid Receptors and Their Role in Behavioural Teratogenicity of Synthetic Glucocorticoids.- Effect of Dithiocarbamate-Fungicides and Thiurams on Haloperidol Binding in Rat Brain.- Toxic Effects on the Gastrointestinal Tract.- Mucosal Biotransformation of Toxins in the Gut.- Intestinal Excretion of Toxic Substances.- Biochemical Changes of Intestinal Epithelial Cells Induced by Cytostatic Agents in Rats.- Intestinal Pathology in the Dog Induced by Sublethal Doses of Amiodarone.- Distribution of Glutathione and its Related Enzymes in Small Intestinal Mucosa of Rats.- Induction of Forestomach Lesions by Butylhydroxyanisole and Structurally Related Substances.- The Effect of Cyclophosphamide and Vincristine on Intestinal Protein Loss in Rats.- The Induction and Assessment of Rat Gastric Mucosal Lesions.- The Technique of Gastric Endoscopy and Biopsy in the Dog.- The Incidence of Neoplasms in Syrian Hamsters with Particular Emphasis on Intestinal Neoplasia.- Toxic Effects on Haemostasis and Blood.- Thrombogenic Effects of Xenobiotics.- Toxicologically Relevant Disturbances of Haemostasis.- Effects of Organic Solvents on Erythrocyte Membrane Acetylcholine Esterase Activity.- Changes of Haemostaseological Variables in Carbon Tetrachloride Poisoning in Rats.- Influence of Antithrombin III on Carbon Tetrachloride Intoxication of Rabbits.- Increased Serum Alkaline Phosphatase Activity in Beagle Dogs: Mechanism, Diagnostic Considerations.- Interaction of Rodenticides and Humic Acids — Effects on Prothrombin Activity.- Interpretation of Concentrations of Toxic Agents during Drug Safety Studies.- Reasons for Monitoring Kinetics in Safety Evaluation Studies.- A Decision Tree Approach for the Application of Drug Metabolism and Kinetic Studies to In Vivo and In Vitro Toxicological and Pharmacological Testing.- Theoretical Aspects Pertinent to the Interpretation of Concentration Data.- How to Identify Compounds Posing Problems in Absorption, Distribution and Elimination.- A Questionnaire Assessing the Involvement of Toxicologists in Metabolism and Kinetics.- A Stochastic Approach in the Evaluation of Plasma Curves with Enterohepatic Recycling.- Endotoxin and Pharmacokinetics of Rifampicin.- Local Toxicity and Pharmacokinetics After Intramuscular or Intralipomatous Injection of Different Drugs in Pigs.- Distribution of Metabolites of the Potent ?-Adrenoceptor Blocking Drug B 24/76 in Different Tissues of Rats under Toxic Conditions.- Functional and Morphological Changes in the Inner Ear.- Principles in Cochlear Toxicity.- Link Between Functional and Morphological Changes in the Inner Ear — Functional Changes Produced by Ototoxic Agents and Their Interactions.- Toxic Effects of Pesticides.- The Effect of Maneb, Zineb and Ethylenethiourea on the Humoral Activity of the Pituitary-Thyroid Axis in Rat.- Toxicokinetics of the Herbicide Dichlorprop and its Leucinate and Their Action on Liver Mixed Function Oxidases.- Organochlorines and Mercury in Blood of a Fish-Eating Population at the River Elbe in Schleswig-Holstein, FRG.- Pesticide-Drug Interaction in Rats.- Dithiocarbamate Fungicides Decrease Histochemical Reactivity of Cholinesterases in the Gut Wall of Rat.- Biochemical Study of Muscle Samples from Chicken Embryos Affected by Wofatox 50 EC.- Investigation of Adrenal Steroid and 25-hydroxy-cholecalcipherol in Human Gramoxone Poisoning.- Group Intoxication with Gramoxone (Paraquat) Toxicological and Pathohistological Aspects.- The Genetic Control of Paraquat Sensitivity of H-2 Congenic and Recombinant Mice.- The Effect of Light on the Toxicity of Paraquat in the Mouse.- Changes of the Serum Superoxide Dismutase Content of Gramoxone Poisoned Patients, Measured by Anti-SOD Monoclonal Antibody.- Cardiodepression in Organophosphate Poisonings.- The Effect of Organophosphoric Pesticides on T- and B-Lymphocytes and Antibody Production in Mice.- Toxicity Study of the Insecticide Ekalux 25 EC in Rats.- Effect of Different Antidotes in Ekalux 25 EC Poisoned Male Rats.- Assessment of Acute Neurotoxic Effects of Different Kinds of Pesticides in Mice.- Subacute and Subchronic Toxicity of Dietary Bendiocarb in Rats.- Effect of Lethal Dose of Trichlorphon on Different Biochemical and Physiological Parameters of Common Carp (Cyprinus Carpio L.).- Chlorate Poisoning: Mechanism of Toxicity.- Effect of Nabam and Ethylenethiourea on the Urinary Output of Rats.- Decis and Perocin Influence on the Activity of Serum Monoamine-Oxidase in Greenhouse Workers.- Immunotoxicological Investigation of the Effects of a Pesticide; Cypermethrin.- Heavy Metal Toxicity.- Effect of Some Heavy Metal Salts on Hepatic Mono-Oxygenases After Subchronic Exposure.- Intestinal Absorption of Aluminium in Rats.- The Formation of Glutathione-Chromium Complexes and Their Possible Role in Chromium Disposition.- Long-Term Exposure to Cadmium and Cardiovascular Alterations in the Rabbit.- Lack of Substantial Neuroendocrine Changes in Short-Term High Dose Cadmium Treated Rats.- Effect of Cadmium on Proteins.- Interaction of Tin and Zinc in Some Processes of Heme Biosynthesis in Rabbits.- The Effect of Chronic Thallium Administration on Testicular Enzyme Activities in the Rat.- Miscellaneous Toxicological Studies.- The Effects of Methylglyoxal on Central Synaptic Transmission in the Isolated Nerve Cord of the Cockroach (Periplaneta Americana L.).- The Role of Bile Acids in the Effect of Ethinylestradiol on the Biliary Excretion Rate of Exogenous Organic Anions.- Substrate and Phenobarbital Induction of the Biliary Excretion of Exogenous Organic Anions in Rats.- The Biliary Elimination of Sulfamerazin in Rat and Man — A Comparison.- Preclinical Safety Studies with Temofel, a New Choleretic Compound.- Studies on Hyperoxaluria and Oxalate Stone Formation Induced by 2-Acetyl-3-PhenylTetrahydro-1,2,4-Oxadiazim-5-on.- The Biliary Elimination of Indomethacin in Man.- Increased Response of Cytochrome P-450 Dependent Biotransformation Reactions in Rat Liver to Repeated Administration of Inducers.- Influence of Pyrazolones on Hepatic Glutathione in Rats.- Comparative Study on the Sensitivity of Several Serum Enzymes in Detecting Hepatic Damage in Rats.- The Metabolism of Some Xenobiotics in Germ-free and Conventionalized Rats.- The Effect of Prostacyclin on the Liver.- Role of Vitamins in Biotransformation of Xenobiotics.- Possible Adrenal Involvement in Hydroxyurea Toxicity Defense Mechanisms.- Replacement Therapy Against Increased Hydroxyurea Toxicity in Pituitary or Adrenal Ablated Rats.- Testicular Toxicity of Antineoplastic Drugs During Postnatal Development of the Rat.- Free and Bound Testosterone in Male Heroin Addicts.- Effect of Single Treatment of Rats with Procarbazine on the Pituitary-Testicular Axis.- Toxic Effects of 3,7-Dimethylxanthine on Mature and Immature Male Rabbits.- Pharmokinetics of Metoprolol in Relation to Polymorphic Sparteine Oxidation.- Mutagenic Metabolites in Rat Urine After Dermal Exposure to 1,3-Diamino-Benzene.- Genotoxicity of Hexachlorobutadiene and Pentachlorobutenoic Acid: Correlation Between Induction of Unscheduled DNA Synthesis and Morphological Transformation in Syrian Hamster Embryo Fibroblasts.- Genotoxic Activity of Nitroimidazo(2,1-b)Thiazole Derivatives in Salmonella Typhimurium and Saccharomyces Cerevisiae Assays.- Serum Enzymes in Toxicity of Trichloroethylene After Subchronic Ethanol Pretreatment.- Oral Intake of a Toluene-Containing Thinner. Effects and Headspace Gas Chromatographic Analytical Diagnosis.- Circadian, Seasonal and Social Factors Influencing the Organic Solvent Toxicity.- Inhalation of Butanols: Changes in the Cytochrome P-450 Enzyme System.- Circulating Steroids in Male Rats Following Inhalation of n-Alcohols.- On the Embryotoxic Effects of Benzene and Its Alkyl Derivatives in Mice, Rats and Rabbits.- Biological Response to Nitrogen Oxide.- The Use of Whole Embryo Culture in the Study of Teratogenic Mechanisms.- Behavioural Tests in the Postnatal Period After Prenatal Administration of Cyclophosphamide to Wistar Rats.- Grip Strength Test and Infrared Thermometry as Non-Invasive Methods to Complement Acute Toxicity Data in Mice.- Behavioural Effects of Prenatal Exposure to Carbon Disulfide and to Aromatol in Rats.- Styrene Metabolism and Striatal Dopamine Depletion in Rabbits.- The Influence of Ethanol Pretreatment and Social Isolation on Dopamine Release and Locomotor Activity in Mice.- Metabolic Fate and Cardiovascular Effects of Arsenic in Rats and Rabbits Chronically Exposed to Trivalent and Pentavalent Arsenic.- Relationships Between the Myocardial Concentrations of Antracycline Antibiotics and Their Cardiotoxic Activity in the Rat.- On the Safety Evaluation of Extracts from Synthetic Polymers Used in Medicine.- Intramuscular Injection and Muscle Damage: Comparison Between Morphological and Enzymatic Changes After Irritants, Drugs and Solvents Administration in Rabbits.- A Six Month Dermal Irritation Test with Anthralins in the Göttingen Miniature Swine.- Separation of Immature and Adult Rat Hepatocytes into Distinct Subpopulations by Centrifugal Elutriation.- Tests for Local Toxicity of Intramuscular Drug Preparations. Comparison of in Vitro and in Vivo Methods.- Analysis of Cataract and Keratotic Damage Induced by 4-Diethylaminoethoxy-?-EthylBenzhydrol (RGH-6201) in Rats.- Applicability of Evans Blue Diffusion for Predicting Eye and Skin Irritancy to Chemicals in the Rat.- Prediction of Toxicity Using Quantitative Structure-Activity Relationships.- Structure-Activity-Adverse Effect Relationships of Condensated As-Triazine Derivatives.- A Mathematical Model Describing the Lethal Effects of High Temperature on Fish and Its Possible Application in the Planning of Toxicological Experiments.- In Vivo Formation of Carcinogenic Substance from Diethyl Pyrocarbonate in the Presence of Ammonia.- Subacute Oral Toxicity of Allyl Isothiocyanate in the Rat.- Preclinical Toxicity Studies with two Thymopoietin-Like Peptides.- Comparative Studies on the Effect of Some Macrolide Antibiotics on Their Own Demethylation.- Ecto-ATPase in Rat and Mouse Thymocytes Cytotoxic Effects of Various Chemical Substances in Vitro.- Toxicity of the Alkylating Agent Bendamustin.- The Leukemogenic Effect of Haloperidol in AKC3 F1 Hybrid Mice.- Author Index.