Contributors vii
Foreword x
Abbreviations xii
Part 1: Overview: From Basic Research to Caring for the Laminitis Patient
1 Historical Perspective on Equine Laminitis 3
Donald M. Walsh and Teresa A. Burns
2 Laminitis: An Overview 11
James K. Belknap
3 Anatomy and Function of the Equine Digit 13
A.H. Parks
4 Lamellar Function at the Cellular Level 22
Christopher C. Pollitt
5 Digital Biomechanics Relevant to Laminitis 39
Jonathan Merritt, Helen Davies and Andrew H. Parks
Part 2: Pathophysiology of Laminitis
6 Overview 51
James K. Belknap
7 Experimental Models of Laminitis: Starch Overload 54
Susan C. Eades
8 Experimental Models of Laminitis: Oligofructose Overload 59
Christopher C. Pollitt and Gabriel J. Milinovich
9 Experimental Models of Laminitis: Black Walnut Extract 64
John F. Peroni
10 Experimental Models of Laminitis: Hyperinsulinemia 68
Catherine McGowan and Janet Patterson-Kane
11 Hemodynamic Events in Laminitis 75
John F. Peroni, Susan C. Eades and Simon R. Bailey
12 The Role of Thrombosis and Coagulation in Equine Laminitis 82
Simon R. Bailey
13 Leukocytes and Inflammatory Signaling in Laminitis: Leukocytes 91
Rafael R. Faleiros and James K. Belknap
14 Leukocytes and Inflammatory Signaling in Laminitis: Inflammatory Signaling 102
Britta Leise
15 Role of Proteases in Laminitis 115
Samuel J. Black, Le Wang, Erica Pawlak, Fengqiu Zhang, John Loftus and Dominique Alfandari
16 Endocrine and Metabolic Dysregulation in Laminitis: Role of Pituitary Dysfunction 134
Philip J. Johnson
17 Endocrine and Metabolic Dysregulation in Laminitis: Role of Corticosteroids 141
Philip J. Johnson
18 Metabolic Syndrome in Humans and Horses: The Relationship Between Obesity and Insulin Resistance 149
Teresa A. Burns and Ramiro E. Toribio
19 Dysregulation of the Lamellar Basal Epithelial Cell in Laminitis: Role of the Cytoskeleton and Cell Junctions 167
Christopher C. Pollitt
20 Structural Dynamics of Displacement of the Distal Phalanx 176
Andrew H. Parks
Part 3: Clinical Presentation of Equine Laminitis
21 General Clinical Aspects of the Laminitis Case 183
Andrew van Eps
22 Sepsis-Related Laminitis 191
Susan C. Eades
23 Laminitis in Equine Metabolic Syndrome 196
Andy E. Durham
24 Laminitis in Pituitary Pars Intermedia Dysfunction 204
Philip J. Johnson
25 Supporting Limb Laminitis 210
Gary M. Baxter
Part 4: Diagnostic Evaluation of Equine Laminitis
26 Detailed Physical Examination for Laminitis 217
Richard A. Mansmann and Hans H. Castelijns
27 Diagnostic Imaging 226
Andrew H. Parks and James K. Belknap
28 The Digital Venogram 240
Amy Rucker
29 Endocrine and Metabolic Evaluation in Horses with Laminitis 252
Ramiro E. Toribio and Teresa A. Burns
Part 5: Medical Treatment of the Laminitic Patient
30 General Supportive Care for the Laminitis Case 269
Andrea E. Floyd and Debra R. Taylor
31 Common Therapies: Anti-Inflammatory Therapy 277
Thomas J. Divers
32 Vasoactive Drug Therapy 284
Simon R. Bailey and Susan C. Eades
33 Analgesia 291
Bernd Driessen and Laura Zarucco
34 Digital Hypothermia 306
Andrew W. van Eps and Christopher C. Pollitt
35 Equine Sepsis 316
Samuel D. Hurcombe and Susan J. Holcombe
36 Equine Metabolic Syndrome 329
Andy E. Durham
37 Pituitary Pars Intermedia Dysfunction 334
Dianne Mcfarlane, Philip J. Johnson and Harold C. Schott, II
Part 6: Treatment of Laminitis: Digital Support and Stabilization of the Distal Phalanx
38 Therapeutic Shoes: Application of Principles 343
Stephen E. O'Grady
39 Solear Support Techniques 354
Raul J. Bras
40 Approaching Digital Management Prior to Displacement of the Distal Phalanx 360
Randy B. Eggleston
41 Hoof Care Management of Horses with Displacement of the Distal Phalanx 364
Andrew H. Parks
Part 7: Treatment of the Laminitis Case
42 The Use of Casts in Equine Laminitis 377
James K. Belknap and Raul J. Bras
43 Deep Digital Flexor Tenotomy 382
R. Wayne Waguespack, Jr
44 Dorsal Hoof Wall Techniques 391
Amy Rucker
45 Complications of Laminitis 402
Robert J. Hunt and James K. Belknap
Part 8: Management of Chronic Laminitis
46 Management Changes in the Laminitis Case 413
Andrew Van Eps, Robert J. Hunt, James K. Belknap and Jeff Ridley
Part 9: Prevention of Laminitis
47 Overview of Laminitis Prevention 423
James K. Belknap and Andy E. Durham
48 Prevention of Supporting Limb Laminitis 427
Harry J. Markwell and Gary M. Baxter
49 Prevention of Sepsis-Related Laminitis 432
Samuel D. Hurcombe and Susan J. Holcombe
50 Nutritional Management for Avoidance of Pasture-Associated Laminitis 436
Pat Harris
Glossary 442
Index 445
