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Produktbild: Quinones and Quinone Enzymes, Part B

Quinones and Quinone Enzymes, Part B Volume 382

177,99 €

inkl. gesetzl. MwSt., Versandkostenfrei


Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

20.02.2004

Herausgeber

Helmut Sies + weitere

Verlag

Elsevier Science & Technology

Seitenzahl

572

Maße (L/B/H)

23,5/15,1/2,8 cm

Gewicht

1085 g

Sprache

Englisch

ISBN

978-0-12-182786-1

Beschreibung

Portrait

Helmut Sies is an Honorary Member of the American Society for Biochemistry and Molecular Biology. He received an Honorary Ph.D. from the University of Buenos Aires, Argentina in 1996. Dr. Sies is a member of the Northrhine-Westphalian Academy of Sciences, Germany, and a Corresponding Member of both the Academy of Sciences of Heidelberg, Germany, and the Academy of Medicine, Buenos Aires, Argentina. He has received many awards and prizes, including the FEBS Anniversary Prize awarded by the Federation of European Biochemical Societies, 1978; the Distinguished Foreign Scholar award, MASUA, 1985; the Silver Medal, Karolinska Institute, Stockholm, 1986; the Ernst Jung Preis fur Medizin, 1988; the Claudius-Galenus-Preis, 1990; and the ISFE-Preis, 1994. Dr. Sies sereves on the editorial board and advisory committee for twelve journals, has edited numerous books, and has published more than 400 original articles and chapters. He received his M.D. at the University of Munich in 1967 and currently serves as Full Professor and Chairman of the Department of Physiological Chemistry at the University of D sseldorf. Lester Packer received a PhD in Microbiology and Biochemistry in 1956 from Yale University. In 1961, he joined the University of California at Berkeley serving as Professor of Cell and Molecular Biology until 2000, and then was appointed Adjunct Professor, Pharmacology and Pharmaceutical Sciences, School of Pharmacy at the University of Southern California. Dr Packer received numerous distinctions including three honorary doctoral degrees, several distinguished Professor appointments. He was awarded Chevalier de l'Ordre National du Merite (Knight of the French National Order of Merit) and later promoted to the rank of Officier. He served as President of the Society for Free Radical Research International (SFRRI), founder and Honorary President of the Oxygen Club of California. He has edited numerous books and published research; some of the most cited articles have become classics in the field of free radical biology: Dr Packer is a member of many professional societies and editorial boards. His research elucidated - the Antioxidant Network concept. Exogenous lipoic acid was discovered to be one of the most potent natural antioxidants and placed as the ultimate reductant or in the pecking order of the "Antioxidant Network regenerating vitamins C and E and stimulating glutathione synthesis, thereby improving the overall cellular antioxidant defense. The Antioxidant Network is a concept addressing the cell's redox status. He established a world-wide network of research programs by supporting and co-organizing conferences on free radical research and redox biology in Asia, Europe, and America.

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

20.02.2004

Herausgeber

Verlag

Elsevier Science & Technology

Seitenzahl

572

Maße (L/B/H)

23,5/15,1/2,8 cm

Gewicht

1085 g

Sprache

Englisch

ISBN

978-0-12-182786-1

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Zeitfracht Medien GmbH
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produktsicherheit@zeitfracht.de

Herstelleradresse

Elsevier Science & Technology
125 London Wall|EC2Y 5AS|London|GB
tradeorders@elsevier.com

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  • Produktbild: Quinones and Quinone Enzymes, Part B
  • Section I: Mitochondrial Ubiquinone and Reductases

    1: Mitochondrial Quinone Reductases: Complex I

    2: Q-Cycle Bypass Reactions at the Qo Site of the Cytochrome bc1 (and Related) Complexes

    3: Targeting Coenzyme Q Derivatives to Mitochondria

    4: The Mitochondrial Interplay of Ubiquinol and Nitric Oxide in Endotoxemia

    5: Mitochondrial Respiratory Chain Dysfunction Caused by Coenzyme Q Deficiency

    6: Coenzyme Q Cytoprotective Mechanisms

    7: Dietary Coenzyme Q10 and Mitochondrial Status

    Section II: Anticancer Quinones and Quinone Oxidoreductases

    8: NAD(P)H:Quinone Oxidoreductase 1 (NQO1, DT-Diaphorase), Functions and Pharmacogenetics

    9: Structure and Mechanism of NAD[P]H:Quinone Acceptor Oxidoreductases (NQO)

    10: Diaziridinylbenzoquinones

    11: Quinone Reductase-Mediated Nitro-Reduction: Clinical Applications

    12: Bioactivation and Resistance to Mitomycin C

    13: NAD(P)H:Quinone Oxidoreductase 1 Expression, Hydrogen Peroxide Levels, and Growth Phase in HeLa Cells

    14: The "Prochaska? Microtiter Plate Bioassay for Inducers of NQO1

    15: Structure-Activity Relationships in Two-Electron Reduction of Quinones

    16: p53-Dependent Apoptosis and NAD(P)H:Quinone Oxidoreductase 1

    17: The Role of Endogenous Catechol Quinones in the Initiation of Cancer and Neurodegenerative Diseases

    18: Induction of NQO1 in Cancer Cells

    Section III: Quinone Reductases: Chemoprevention and Nutrition

    19: Role of Nicotinamide Quinone Oxidoreductase 1 (NQO1) in Protection against Toxicity of Electrophiles and Reactive Oxygen Intermediates

    20: Activation and Detoxification of Naphthoquinones by NAD(P)H: Quinone Oxidoreductase

    21: Induction of Quinone Reductase as a Primary Screen for Natural Product Anticarcinogens

    22: Chemoprevention by 1,2-Dithiole-3-Thiones Through Induction of NQO1 and Other Phase 2 Enzymes

    23: Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

    24: Induction of Phase II Enzymes by Aliphatic Sulfides Derived from Garlic and Onions: An Overview

    25: Upregulation of Quinone Reductase by Glucosinolate Hydrolysis Products From Dietary Broccoli

    Section IV: Quinones and Age-Related Diseases

    26: Therapeutic Effects of Coenzyme Q10 in Neurodegenerative Diseases

    27: Neuroprotective Actions of Coenzyme Q10 in Parkinson's Disease

    Author Index

    Subject Index