Produktbild: Drug Discovery

Drug Discovery

161,99 €

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.04.2013

Herausgeber

Jie Jack Li + weitere

Verlag

John Wiley & Sons Inc

Seitenzahl

570

Maße (L/B/H)

26/18,3/3,5 cm

Gewicht

1259 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-94235-2

Beschreibung

Rezension

"Taken together, the book is an excellent introduction into drug discovery and an eminent summary of the very important milestones of drug discovery in the most critical indication areas. This book is a valuable addition to the library of all different kinds of scientists working in the field of drug discovery." ( ChemMedChem , 1 October 2013)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.04.2013

Herausgeber

Verlag

John Wiley & Sons Inc

Seitenzahl

570

Maße (L/B/H)

26/18,3/3,5 cm

Gewicht

1259 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-470-94235-2

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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Die Leseprobe wird geladen.
  • Produktbild: Drug Discovery
  • Chapter 1. History of Drug Discovery 1
     
    1. Introduction 1
     
    2. Antibacterials 1
     
    3. Cancer Drugs 6
     
    4. Cardiovascular Drugs 10
     
    5. Cholesterol Drugs 16
     
    6. CNS Drugs 21
     
    7. Anti-inflammatory Drugs 26
     
    8. Anti-ulcer Drugs 30
     
    9. Antiviral Drugs 33
     
    10. References 38
     
    Chapter 2. Target Identification and Validation 43
     
    1. History 43
     
    2. Definition of Drug Targets 43

    3. Classification of Currently Utilized Drug Targets 45
     
    4. Receptors as Drug Targets 46
     
    5. Enzymes as Drug Targets 48
     
    6. Transporter Proteins as Drug Targets 49
     
    7. Modern Technologies Employed in Target Identification and Validation 49
     
    8. Impact of Therapeutic Modalities on the Selection Drug Targets 62
     
    9. Future Directions 63
     
    10. References
     
    3. In vitro and in vivo Assays 67
     
    1. Introduction 67
     
    2. The Testing Funnel 67
     
    3. In vitro assays 70
     
    4. In vivo Assays 89
     
    5. Outlook 92
     
    6. References 93
     
    Chapter 4. Drug Metabolism and Pharmacokinetics in Drug Discovery 95
     
    1. Introduction 95
     
    2. Drug Metabolism 97
     
    3. Pharmacokinetic Fundamentals 106
     
    4. Drug Metabolism and Pharmacokinetics in Drug Discovery 95
     
    1. Introduction 95
     
    2. Drug Metabolism 97
     
    3. Pharmacokinetic Fundamentals 106
     
    4. Pharmacokinetics Studies in Support of Drug Optimization 112
     
    5. Absorption and Permeability 114
     
    6. Drug Transporters 117
     
    7. Protein Binding 119
     
    8. Pharmacokinetics and Pharmacodynamics 123
     
    9. Predicting Human Pharmacokinetics 130
     
    10. Summary 133
     
    11. References 133
     
    Chapter 5. Cardiovascular Drugs 137
     
    1. Introduction 137
     
    2. Early History of Coronary Heart Disease (CHD) 138
     
    3. Lipid Lowering Agents 139
     
    4. Antihypertensive Agents 153
     
    5. Antithrombotic Drugs 177
     
    6. Thrombolytic Agents 190
     
    7. Anti-anginal Agents 191
     
    8. Heart Failure Drugs 191
     
    9. The Future 193
     
    10. References 193
     
    Chapter 6. Diabetes Drugs 201
     
    1. Introduction 201
     
    2. Current therapies for Type 2 Diabetes 204
     
    3. Other Treatments for T2DM 215
     
    4. Novel Mechanisms of Action: Future Treatments for Type 2 Diabetes 217
     
    5. Current Therapies for Type 1 Diabetes 221
     
    6. Future Treatments for Type 1 Diabetes 227
     
    7. Future Prospects for New Diabetes Drugs 231
     
    8. References 231
     
    Chapter 7. CNS Drugs 241
     
    1. Introduction 241
     
    2. Antipsychotic Drugs 241
     
    3. Antidepressant drugs 246
     
    4. Drugs for Epilepsy and Bipolar Disorder 255
     
    5. Anxiolytic Drugs 259
     
    6. Centrally Acting Analgesic Drugs 262
     
    7. Drugs for treating Substance Abuse and ADHD 265
     
    8. Drugs for Neurodegenerative Diseases 267
     
    9. Future Prospects for New CNS Drugs 273
     
    10. References 276
     
    Chapter 8. Cancer Drugs 283
     
    1. Introduction 283
     
    2. Historical Perspective of Cancer Drugs 285
     
    3. Antimetabolites 286
     
    4. Alkylating Agents 291
     
    5. Platinum Complexes 294
     
    6. Plant and Marine Based Natural Products 295
     
    7. Toposiomerase Inhibitors 300
     
    8. Antitumor Antibiotics 305
     
    9. Tyrosine Kinase Inhibitors (TKI) 306
     
    10. Hormones 314
     
    11. Histone Deacylase (HDAC) Inhibitors 321
     
    12. Miscellaneous Cancer Drugs 323