Transplantation of Composite Tissue Allografts

PRINTED IN THE JULY 2008 ISSUE OF ANNALS OF PLASTIC SURGERY

Hewitt CW, Lee WPA, Gordon CR, eds. Transplantation of Composite Tissue Allografts. New York: Springer; 2008, 498 pp, $169.00.

Some books are indispensable to their times. Forty years ago, plastic surgeons were redefining many surgical problems and much of their surgical thinking into more rigorous biologic concepts of wound healing.

I believe that Transplantation of Composite Tissue Allografts is, likewise, an indispensable book for the developing era of reconstructive transplantation. This field should broadly engage reconstructive plastic surgeons. While organ transplantation, though clinically pioneered by Nobel-laureate plastic surgeon Joseph Murray, could readily move into the realm of general surgery technique, composite transplantation of limbs and facial units will necessarily demand the skills of microsurgery, peripheral nerve surgery, and reconstructive surgery provided by plastic surgeons. Plastic surgeons who hope to participate in these developments (or even intelligently follow them) should read this book.

The book is a multiauthored text, but it is a competently organized one, with good coordination of contributions and minimal redundancy. Current biologic concepts and clinical application of composite tissue transplantation are presented with detail and intelligent interpretation.

The section on immunosuppression and tolerance are excellent summaries of these experimental concepts and current clinical applications. The persistent hazards of immunosuppression and the elusiveness of induced tolerance are honestly summarized. Thorough descriptions of immunosuppressive agents and immunologic strategies are valuable parts of these sections.

The clinical summaries of composite tissue transplants to date illustrate the potentials and problems of these procedures. This reading, however, further impressed me with the utility of the bilateral hand transplant procedures. Careful analysis of transplantation cases as presented in this book will be the invaluable basis for judging clinical results and projecting applications in the future of reconstructive transplantation.

I congratulate the editors and authors on the timely and well-executed volume. I recommend it highly.

William C. Lineaweaver, MD

Editor

1. Peacock E, Van Winkle W. Surgery and biology of wound repair.

2. Lineaweaver W. Chronic rejection, hand transplantation, and the monkey's paw (editorial). Microsurgery. 2006;26:419.