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  • Produktbild: Cytotoxic Drug Resistance Mechanisms
  • Produktbild: Cytotoxic Drug Resistance Mechanisms
Band 28 - 11%

Cytotoxic Drug Resistance Mechanisms

Aus der Reihe Methods in Molecular Medicine
11% sparen

96,99 € UVP 109,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

05.04.1999

Herausgeber

Robert Brown + weitere

Verlag

Humana Press

Seitenzahl

238

Maße (L/B/H)

23,5/15,7/1,9 cm

Gewicht

549 g

Auflage

1999

Sprache

Englisch

ISBN

978-0-89603-603-1

Beschreibung

Rezension

"This timely book will greatly benefit a wide array of individuals interested in cancer therapeutics, at both the clinical and basic science level. The editors and contributors did a good job of concisely presenting otherwise disparate methodologies in the context of a broad research field with the uniting purpose of understanding the biology underlying resistance to cancer chemotherapy. "-Doody's Health Sciences Book Review Journal

"...the editors have managed to successfully compile a brief review of cytotoxic drug resistance mechanisms and an extensive manual of protocols for laboratory experimentation in this extremely important area of research. It is clear that any laboratory scientist in this field must be aware of the difficulty of translation to the clinic of anti-drug resistance lead compounds, and should keep a copy of this book within reach. Congratulations to the editors for assembling an important mix of laboratory and clinical scientists to create this volume."-The Quarterly Review of Biology

"This book provides a comprehensive guide to a range of methods to a diverse range of drug resistance mechanisms including: Multidrug resistance (P-glycoprotein and MDR-1 gene analysis); cell sensitivity (clonogenic and MTT assays); Apoptosis (TUNEL, p 53 and Bcl-2); Glutathione-associated resistance (enzyme based glutathione assay and a HPLC method for reduced glutathione); DNA repair defects and damage (topoisomerase activity assays and DNA adduct measurements); 5-Fluorouracil metabolizing enzymes; Genetic analysis including microsatellite instability and fluorescence in situ hybridization....The methods are clearly described with each chapter consisting of an introduction and well described materials and methods sections. An extremely useful addition to most chapters was the "Notes" section where the respective authors suggest very useful hints, problem solving approaches and advice on the interpretation of results....the book is well written and useful addition to any laboratory investigating drug resistance in either clinical samples or tumor cell lines."-Cancer Forum

"...a useful collection of protocols that can be used in the oncology laboratory for studies on drug resistance and molecular pharmacology....It should find its place on the library shelves of many laboratories of oncology."- Annals of Oncology

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

05.04.1999

Herausgeber

Verlag

Humana Press

Seitenzahl

238

Maße (L/B/H)

23,5/15,7/1,9 cm

Gewicht

549 g

Auflage

1999

Sprache

Englisch

ISBN

978-0-89603-603-1

Herstelleradresse

Springer-Verlag GmbH
Tiergartenstr. 17
69121 Heidelberg
DE

Email: ProductSafety@springernature.com

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  • Produktbild: Cytotoxic Drug Resistance Mechanisms
  • Produktbild: Cytotoxic Drug Resistance Mechanisms
  • Drug Resistance: The Clinical Perspective
    D. Alan Anthoney and Stanley B. Kaye

    Cell Sensitivity Assays: Clonogenic Assay
    Jane A. Plumb

    Cell Sensitivity Assays: The MTT Assay
    Jane A. Plumb

    Cell Sensitivity Assays: Detection of Apoptotic Cells In Vitro Using the TUNEL Assay
    Neil A. Jones and Caroline Dive

    Analysis of Apoptosis in Tissue Sections
    Vicki Save, Philip J. Coates, and Peter A. Hall

    Measurement of P-glycoprotein Function
    Henk J. Broxterman

    Measuring MDR-1 by Quantitative RT-PCR
    Susan E. Bates, Zhirong Zhan, Joanna Regis, and Erick Gamelin

    Microtiter Plate Technique for the Measurement of Glutathione in Fresh and Cryopreserved Lymphoblasts Using the Enzyme Recycling Method
    Pamela R. Kearns and Andrew G. Hall

    Measurement of Reduced Glutathione Using High Pressure Liquid Chromatography
    Linda A. Hogarth, Celia M. A. Rabello, and Andrew G. Hall

    Topoisomerase I and II Activity Assays
    Philippe Pourquier, Glenda Kohlhagen, Li-Ming Ueng, and Yves Pommier

    5-Fluorouracil Metabolizing Enzymes
    Howard L. McLeod, Lesley H. Milne, and Stephen J. Johnston

    Measuring DNA Adducts by Immunoassay (ELISA)
    Michael J. Tilby

    Measuring Drug-DNA Adducts in Individual Cells
    Adrian J. Frank

    Measurement of Drug-Induced DNA Interstrand Crosslinking Using the Single Cell Electrophoresis (Comet) Assay
    Victoria J. Spanswick, Janet M. Hartley, Timothy H. Ward, and John A. Hartley

    PCR Analysis of Microsatellite Instability
    Gillian L. Hirst

    O 6-Alkylguanine-DNA Alkyltransferase Assay
    Amanda J. Watson and Geoffrey P. Margison

    Analysis of the p53 Status of Tumors: An Overview of Methods
    Jonas Bergh

    Bcl-2 Family Immunohistochemistry
    Lloyd R. Kelland and Philip J. Beale

    Genetic Analysis of Drug Resistance by Fluorescence In Situ Hybridization
    W. Nicol Keith

    Genetic Analysis of Drug Resistance by ReverseIn Situ Hybridization
    W. Nicol Keith

    Index