Produktbild: Computer Applications in Pharmaceutical Research and Development

Computer Applications in Pharmaceutical Research and Development

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Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.06.2006

Herausgeber

Sean Ekins

Verlag

John Wiley & Sons Inc

Seitenzahl

832

Maße (L/B/H)

24,2/16,4/4,5 cm

Gewicht

1287 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-471-73779-7

Beschreibung

Rezension

"...a well-put-together volume with a lot of very interesting andtimely information to convey...it would be a nice addition toindividual, academic, and industrial libraries." ( Journal ofMedicinal Chemistry , December 28, 2006)
"...strongly recommended both to the structural and medicinalchemistry community, and also to...computational chemists...thewhole book is really very readable and enjoyable." ( StructuralChemistry , December 2006)

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

01.06.2006

Herausgeber

Sean Ekins

Verlag

John Wiley & Sons Inc

Seitenzahl

832

Maße (L/B/H)

24,2/16,4/4,5 cm

Gewicht

1287 g

Auflage

1. Auflage

Sprache

Englisch

ISBN

978-0-471-73779-7

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: gpsr@libri.de

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  • Produktbild: Computer Applications in Pharmaceutical Research and Development
  • Preface xi

    Acknowledgments xiii

    Contributors xv

    Part I: Computers in Pharmaceutical Research And Development: a General Overview 1

    1. History of Computers in Pharmaceutical Research and Development: A Narrative 3
    Donald B. Boyd and Max M. Marsh

    2. Computers as Data Analysis and Data Management Tools in Preclinical Development 51
    Weiyong Li and Kenneth Banks

    3. Statistical Modeling in Pharmaceutical Research and Development 67
    Andrea de Gaetano, Simona Panunzi, Benoit Beck, and Bruno Boulanger Copyrighted Material

    Part II: Understanding Diseases: Mining Complex Systems for Knowledge 103

    4. Drug Discovery from Historic Herbal Texts 105
    Eric J. Buenz

    5. Contextualizing the Impact of Bioinformatics on Preclinical Drug and Vaccine Discovery 121
    Darren R. Flower

    6. Systems Approaches for Pharmaceutical Research and Development 139
    Sean Ekins and Craig N. Giroux

    Part III: Scientific Information Handling and Enhancing Productivity 167

    7. Information Management-Biodata in Life Sciences 169
    Richard K. Scott and Anthony Parsons

    8. Chemoinformatics Techniques for Processing Chemical Structure Databases 187
    Valerie J. Gillet and Peter Willett

    9. Electronic Laboratory Notebooks 209
    Alfred Nehme and Robert A. Scoffin

    10. Strategies for Using Information Effectively in Early-Stage Drug Discovery 229
    David J. Wild

    11. Improving the Pharmaceutical R&D Process: How Simulation Can Support Management Decision Making 247
    Andrew Chadwick, Jonathan Moore, Maggie A.Z. Hupcey, and Robin Purshouse

    Part IV: Computers in Drug Discovery 275

    12. Computers and Protein Crystallography 277
    David J. Edwards and Roderick E. Hubbard

    13. Computers, Cheminformatics, and the Medicinal Chemist 301
    Weifan Zheng and Michael Jones

    14. The Challenges of Making Useful Protein-Ligand Free Energy Predictions for Drug Discovery 321
    Jun Shimada

    15. Computer Algorithms for Selecting Molecule Libraries for Synthesis 353
    Konstantin V. Balakin, Nikolay P. Savchuk, and Alex Kiselyov

    16. Success Stories of Computer-Aided Design 377
    Hugo Kubinyi

    17. Pharmaceutical Research and Development Productivity: Can Software Help? 425
    Christophe G. Lambert and S. Stanley Young

    Part V: Computers in Preclinical Development 443

    18. Computer Methods for Predicting Drug Metabolism 445
    Sean Ekins

    19. Computers in Toxicology and Risk Assessment 469
    John C. Dearden

    20. Computational Modeling of Drug Disposition 495
    Cheng Chang and Peter W. Swaan

    21. Computer Simulations in Pharmacokinetics and Pharmacodynamics: Rediscovering Systems Physiology in the 21st Century 513
    Paolo Vicini

    22. Predictive Models for Better Decisions: From Understanding Physiology to Optimizing Trial Design 529
    James R. Bosley, Jr.

    Part VI: Computers in Development Decision Making, Economics, and Market Analysis 555

    23. Making Pharmaceutical Development More Efficient 557
    Michael Rosenberg and Richard Farris

    24. Use of Interactive Software in Medical Decision Making 571
    Renée J. Goldberg Arnold

    Part VII: Computers in Clinical Development 591

    25. Clinical Data Collection and Management 593
    Mazen Abdellatif

    26. Regulation of Computer Systems 633
    Sandy Weinberg

    27. A New Paradigm for Analyzing Adverse Drug Events 649
    Ana Szarfman, Jonathan G. Levine, and Joseph M. Tonning

    Part VIII: Further Applications and Future Development 677

    28. Computers in Pharmaceutical Formulation 679
    Raymond C. Rowe and Elizabeth A. Colbourn

    29. Legal Protection of Innovative Uses of Computers in R&D 703
    Robert Harrison

    30. The Ethics of Computing in Pharmaceutical Research 715
    Matthew K. McGowan and Richard J. McGowan

    31. The UltraLink: An Expert System for Contextual Hyperlinking in Knowledge Management 729
    Martin Romacker, Nicolas Grandjean, Pierre Parisot, Olivier Kreim, Daniel Cronenberger, Thérèse Vachon, and Manuel C. Peitsch

    32. Powerful, Predictive, and Pervasive: The Future of Computers in the Pharmaceutical Industry 753
    Nick Davies, Heather Ahlborn, and Stuart Henderson

    Index 775