Basic Aspects of Protein Degradation Through the Ubiquitin Proteasome System (UPS).- Yeast Proteasome Structure and Biogenesis.- Ubiquitin-Proteasome System in the Central Nervous System.- Protein Aggregation, Inclusion Formation and Ups Function.- Protein Aggregation and the UPS: A Two-Way Street.- The Impact of Inclusion Formation on Cell Survival.- Inclusion Formation and Disolution Following Proteasomal Inhibition in Neuronal Cells.- Oxidative Stress and Ups Function.- The Proteasome: Source and a Target of Oxidative Stress?.- Inflammation as a Mediator of Oxidative Stress and UPS Dysfunction.- Proteasome and Neuronal Cell Death and Survival.- Role of the Ubiquitin Proteasome System During Neuronal Cell Death.- Pathways of Neuronal Cell Death Induced by Proteasomal Inhibition.- Models of Dysfunction of the UPS and the Proteasome.- Pharmacological and Molecular Models of Proteasomal Dysfunction.- The Gad Mouse: A Window Into UPS-Related Neurodegeneration and the Function of the Function of the Deubiquitinating Enzyme Uch-L1.- The UPS in Neurodegenerative Diseases and Aging.- Parkinson’s Disease and Related Disorders.- Ubiquitination by Parkin — Implications in Parkinson’s Disease.- The Ups in Neurodegenerative Diseases and Aging Huntington’s Disease.- Frameshift Mutant Ubiquitin in Alzheimer’s Disease and Other Neurodegenerative Disorders.- Motor Neuron Disease.- The Paradoxical Role of Proteasomes in Prion Disorders.- Aging and the Proteasome.