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Produktbild: Ion Channels and Ion Pumps
Band 6

Ion Channels and Ion Pumps Metabolic and Endocrine Relationships in Biology and Clinical Medicine

Aus der Reihe Endocrinology and Metabolism

118,99 €

inkl. gesetzl. MwSt., Versandkostenfrei

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

23.12.1993

Abbildungen

XX, 587 p.

Herausgeber

Piero P. Foa + weitere

Verlag

Springer Us

Seitenzahl

587

Maße (L/B/H)

3,1/16/24 cm

Gewicht

1020 g

Auflage

1994

Sprache

Englisch

ISBN

978-0-387-94083-0

Beschreibung

Produktdetails

Einband

Gebundene Ausgabe

Erscheinungsdatum

23.12.1993

Abbildungen

XX, 587 p.

Herausgeber

Verlag

Springer Us

Seitenzahl

587

Maße (L/B/H)

3,1/16/24 cm

Gewicht

1020 g

Auflage

1994

Sprache

Englisch

ISBN

978-0-387-94083-0

Herstelleradresse

Libri GmbH
Europaallee 1
36244 Bad Hersfeld
DE

Email: GPSR Kontakt

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  • Produktbild: Ion Channels and Ion Pumps
  • Preface.- Contributors.- 1. The Molecular Structure and Gating of Calcium Channels.- Multiplicity of Voltage-Dependent Calcium Channels.- Structure of a Skeletal Muscle L-Type Calcium Channel.- The Roles of D HP-Binding Proteins in Skeletal Muscle.- Homologous Calcium Channels.- Gating of Voltage-Dependent Calcium Channels.- Structure-Function Relationships of VDCCs.- Regulation of Calcium Channels.- Conclusion.- 2. Calcium Signals in Cell Proliferation, Differentiation, and Death.- Cell Cycle Signals.- Liver Regeneration.- Keratinocytes.- 3. Role of Calcium in Stimulus-Secretion Coupling in Exocrine Glands.- Requirement for Calcium in Exocrine Secretion.- Calcium Entry, Release, and Efflux Mechanisms.- Cellular Mechanisms Involved in Agonist-Stimulated Increases in Intracellular Calcium in Exocrine Cells.- Summary and Conclusions.- 4. Calcium Channels, the Pancreatic Islet, and Endocrine Secretion.- Ion Channels in ß Cells.- Calcium Channels in a Cells.- Conclusions.- 5. Calcium Channels in Cells of the Anterior Pituitary.- General Properties of Calcium Channels in Pituitary Cells.- Calcium Channels in Pituitary Lactotrophs.- Calcium Channels in Somatotrophs.- Calcium Channels in Corticotrophs and Thyrotrophs.- Calcium Channels in Gonadotrophs.- Conclusion.- 6. Role of Calcium in the Secretion of Atrial Natriuretic Peptide.- The Langendorff Preparation.- Isolated Atrial Preparations.- Cardiomyocytes in Culture.- 7. Intracellular Ca2+ and Insulin Action: Possible Role in the Pathogenesis of Syndrome X.- Physiologic Regulation of the Intracellular Calcium Concentration.- The Role of [Ca2+]i in Insulin Action and Insulin Resistance.- Abnormal [Ca2+]i Homeostasis in Diabetes.- Abnormal [Ca2+]i Homeostasis in Hypertension and Obesity.- Abnormal [Ca2+]i and Syndrome X.- High [Ca2+]i and Atherosclerosis.- Conclusions.- 8. [Ca2+]i and Contraction of Arterial Smooth Muscle.- Regulation of Myoplasmic [Ca2+].- Regulation of Myosin Light Chain Phosphorylation ([Ca2+]i Sensitivity).- Regulation of Contractile Force (The Latch Phenomenon).- Conclusion.- 9. Autoimmunity Against the Nicotinic Acetylcholine Receptor and the Presynaptic Calcium Channel at the Neuromuscular Junction.- Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome: A Brief History.- The Autoantigen in MG: Structure of the Nicotinic Acetylcholine Receptor.- The Autoantigen in LEMS: Structure and Function of the co-Conotoxin-Sensitive VOCC.- The Effectors of Myasthenic Symptoms: Autoantibodies Against Membrane Proteins Involved in the Cholinergic Transmission.- B and T Epitopes on the AChR Molecule.- Pathogenetic Mechanisms in MG.- Pathogenetic Mechanisms of LEMS.- Possible Similarities in the Pathogenesis of LEMS and MG.- 10. Clinical Pharmacology of Calcium Channels.- Classification of Plasmalemmal Calcium Channels.- Classification of Calcium Channel Modulators.- Clinical Profile and Tissue Selectivity.- Basis for Tissue Selectivity of L-Channel Antagonists.- Clinical Use of Ca2+ Antagonists.- Conclusion.- 11. Hormonal Modulation of Sodium Pump Activity: Identification of Second Messengers.- Adrenal Glomerulosa Cells.- Heart.- Skeletal Muscle.- Liver.- HeLa Cells Transfected with the 5-HT1A Receptor.- Platelets.- Neurons.- Kidney.- Rat Brain Synaptosomes.- Adipocytes.- Summary.- 12. Endogenous Regulation of Sodium Pump Activity.- Volume Expansion and Sodium Pump Inhibitor.- Sodium Pump Inhibitor and Hypertension.- Cellular Mechanisms Linking Hypertension, Fluid Balance, and the Sodium Pump.- The Search for an Endogenous Digitalis-Like Factor (EDLF).- Possible Sources of Endogenous Digitalis-Like Factor.- Sodium Pump Inhibition in the Clinical Setting.- Conclusion.- 13. Structure, Gating, and Clinical Implications of the Potassium Channel.- An Approach to the Study of Potassium Channels.- Biophysical Properties.- Different Types of Potassium Channel Conductance.- Clinical Implications.- Conclusions.- 14. Potassium Channels in Skeletal Muscle.- Ionic Channels in Skeletal Muscle.- Involvement of Potassium Channels in Selected Muscle Diseases.- Conclusions.- 15. The Role of Potassium Ions in the Control of Heart Function.- Permeability.- Rectification.- The Delayed Rectifier (IKdr).- The Inward Rectifier (IKir).- The Transient Outward Current (IKto).- The Calcium-Dependent Potassium Current (IKCa).- The [ATP] i-Dependent Potassium Current (IKATP).- The ACh-Sensitive Potassium Current (IKACh).- The Na-Dependent Potassium Current (IKNa).- The Arachidonic Acid-Activated Potassium Current (IKAA).- The Plateau-Potential Potassium Current (IKP).- Summary.- 16. Nonrenal Potassium Homeostasis: Hypokalemia and Potassium Depletion - Role of Skeletal Muscle Potassium-Pump (Na+,K+ -ATPase).- Body Potassium Homeostasis.- Skeletal Muscles and Potassium Homeostasis.- Rapid Regulation of the Na,K Pump in Skeletal Muscle.- Long-Term Regulation of the Na,K Pump in Skeletal Muscle.- Etiology of Hypokalemia and Potassium Depletion.- Methods for the Assessment of Hypokalemia and Potassium-Depletion.- Consequences of Hypokalemia and Potassium Depletion.- Therapy of Hypokalemia and Potassium Depletion.- Conclusion.- 17. The Clinical Pharmacology of Potassium Channels.- Role of Potassium Channels in Cell Function.- Potassium-Channel Subtypes.- Hypoglycemic Sulphonylureas.- Class III Anti-Arrhythmics.- Drug Design Based on the Structure of Potassium-Channel Toxins.- Potassium-Channel Openers.- Conclusion.- 18. Ion Transport in Vascular Smooth Muscle and the Pathogenesis of Hypertension.- Ion Transport in Vascular Smooth Muscle and How This Relates to Contraction.- Pathophysiologic Changes in the Vasculature in Essential Hypertension.- Conclusion.- 19. Calcium Ion Homeostasis in the Aging Brain: Regulation of Voltage-Dependent Calcium Channels.- Calcium Ion Homeostasis at the Neuronal Level.- Calcium and the Aging Nervous System.- VDCC and Brain Aging.- Functional Expression of VDCC During Aging.- Conclusions.- 20. Interactions of Ethanol with Ion Channels: Possible Implications for Mechanisms of Intoxication and Dependence.- Ethanol and Cellular Calcium Mechanisms.- ET-OH and Na+,K+-ATPase (NKA).- ET-OH and the Na+ Channel.- ET-OH and NMD A-Activated Ion Current.- ET-OH Interaction with GABA-Induced Chloride Current.- ET-OH and 5-HT-3 Receptor.- Conclusions.- 21. Structure and Function of Receptor-Mediated Chloride Channels in the Central Nervous System.- The GABAA Receptor-Mediated CI~ Channel.- Glycine Receptor-Mediated CI~ Channels.- Conclusions.- 22. Characterization of Ion Channels in the Central Nervous System: Insights from Radioligand Binding, Autoradiography, and In Situ Hybridization Histochemistry.- Classes of Ion Channels and Their Roles in the CNS.- Techniques for the Detection of Ion Channels in the CNS.- Studies of Ion Channel/Receptor Recognition Sites Using Radioligands.- Neuroanatomic Localization of Ion Channel/Receptors by In Vitro Autoradiography.- Cellular and Anatomic Localization of Ion Channel/Receptor Expression by In Situ Hybridization Histochemistry.- Studies of Ion Channel Receptor Proteins in Human Brain and Clinical Applications of Ion Channel Research.- Future Developments.- 23. Chloride Channels in Cystic Fibrosis.- Historical Perspective.- CI~ Channels in Epithelia.- Respiratory System.- Intestinal Tract.- Sweat Gland.- Future Considerations.- 24. Cyclic Nucleotide-Activated Channels.- Transduction-Excitation Coupling in Sensory Systems.- Ion Permeation Through Cyclic Nucleotide-Activated Channels.- Structure of Cyclic Nucleotide-Activated Channels.- 25. Transport Systems for Arsenic, Antimony, and Cadmium Ions Encoded by Bacterial Plasmids.- Plasmid-Encoded Transport of Oxyanions of Arsenic and Antimony.- Plasmid-Mediated Cadmium Resistance in Staphylococcus aureus.- Cadmium, Zinc, and Cobalt Resistance in Alcaligenes eutrophus.- Conclusion.